Article

Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.

Laboratory of Pediatric Onco-Hematology, Department of Pediatrics, University Hospital of Padua, Padua, Italy.
Haematologica (Impact Factor: 5.94). 06/2006; 91(5 Suppl):ECR09.
Source: PubMed

ABSTRACT An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.

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May 23, 2014