Gastric signet-ring adenocarcinoma presenting with breast metastasis

3rd Department of Clinical Oncology, Theagenion Cancer Hospital, 54007, Thessaloniki, Greece.
World Journal of Gastroenterology (Impact Factor: 2.37). 06/2006; 12(18):2958-61.
Source: PubMed


Breast metastases from gastric cancer are extremely rare. A case report of a 37-year-old female with breast inflammatory invasion and ascites is described. Breast biopsy revealed carcinomatous invasion of the lymphatics from adenocarcinoma cells with signet-ring features. Estrogen (ER) and progesterone receptors (PR) and c-erb-B2 were negative. Upper gastrointestinal endoscopy revealed a prepyloric ulcerative mass. Histopathologic examination of the lesion showed infiltration from a high-grade adenocarcinoma, identical with that of the breast. Immunostaining was positive for cytokeratins CK-7 and CK-20 and CEA and negative for ER and PR. Ascitic fluid cytology was positive for adenocarcinoma cells. Mammography was not diagnostic. Abdominal CT scanning revealed large ovarian masses suggestive of metastases (Krukenberg's tumor). A cisplatin-based regimen was given but no objective response was observed. The patient died six months after initial diagnosis. A review of the literature is performed.

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    • "Breast metastases from other tumors are extremely rare and constituting 2% of all breast cancers (Yeh et al., 2004). The most primary malignancies metastasizing to the breast are as follows; malign melanom, lung tumors, carcinoid tumors, ovarian tumors, renal cell tumors and gastrointestinal tumors (Boutis et al., 2006). We report a rare case of gastric adenocarcinoma metastasizing to the breast. "
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    ABSTRACT: ARTICLE INFO ABSTRACT Metastasis of gastric carcinoma to the breast is relatively uncommon. It may cause diffi-culty in differentiating metastasis from primary breast cancer. Our patient was 64 year-old woman presented with dysphagia, weight loss and mass on right breast. Mammography showed mass on the right breast and computerized tomographic scan of the abdomen showed thickening of the gastric cardia and small curvature. Pathological evaluation of both breast mass and gastric lesion showed that there is a primary gastric carcinoma and the mass on the breast is the metastasis of this primary gastric carcinoma. In this report; we present a case of gastric carcinoma with metastasis to the breast.
    05/2011; 28(1). DOI:10.5835/jecm.omu.28.1.006
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    • "Marked fibrosis with the presence of loose cells of big size and wide cytoplasm, positive with PAS technique. The morphology is comparable to the gastric carcinoma diagnosed two months earlier. of CK 20 and CEA positive staining in conjunction with negative ER staining strongly supports a diagnosis consistent with gastrointestinal primary adenocarcinoma rather than a primary breast carcinoma [2] [3] [5] [6] "
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    ABSTRACT: Metastatic tumors in the breast are quite rare and constitute 0,5 to 6% of all breast malignancies. They often occur in a polymetastatic context. Gastrointestinal lesions rarely metastasize to the breast. The first case of a metastasis deposit to the breast and ovary from gastric signet-ring cell carcinoma was reported in the literature in 1999. Since this report, only 5 cases have been reported. We present a case report of a 37-year-old woman who complained of a lump in the left breast. Two months earlier, the woman underwent a subtotal gastrectomy and a total hysterectomy with double anexectomy, which histologically was diagnosed of gastric signet-ring carcinoma, disseminated with Krukenberg's tumor. In those days, the patient was following a chemotherapy treatment. A core needle biopsy of the lesion in left breast revealed cells with signet-ring features, with probably gastric origin.
    ISRN obstetrics and gynecology 01/2011; 2011(2):426150. DOI:10.5402/2011/426150
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    ABSTRACT: ObjectiveTo analyze the clinicopathologic features of breast signet-ring cell carcinoma (SRCC) presenting with genital tract metastasis. MethodsA 54-year-old woman presented with metrorrhagia was described and the immunostaining was performed. ResultsHistologically, signet ring cells (SRCs) scattered in the stroma of endometrium and cervix, bilateral fallopian tubes, ovaries and left breast. Immunohistochemistry of these SRCs showed strong reactive for cytokertin 7, CEA, GCDFP-15, and weak reactive for CA125 and negative for cytokertin 20. All these information confirmed the breast origin of SRCC. ConclusionPrimary breast SRCC is extremely rare with metrorrhagia as its first symptom. Gynecologist and pathologist should be aware of this possibility when metrorrhagia is the only symptom. Immunohistochemistry can help differentiate the origin of SRCC.
    The Chinese-German Journal of Clinical Oncology 07/2008; 7(7):410-412. DOI:10.1007/s10330-007-0195-0
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