Article

Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp.

Cancer Research Institute, Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 872404, Tempe, Arizona 85287-2404, USA.
Journal of Natural Products (impact factor: 3.13). 06/2006; 69(5):804-6. DOI:10.1021/np058087v pp.804-6
Source: PubMed

ABSTRACT A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 microg/mL) growth of a minipanel of human cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit cancer cell growth.

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Keywords

bacteria Streptococcus pneumoniae
 
cancer cell growth
 
cancer cell growth inhibitories
 
companion constituents
 
cyclo-Pro-Leu
 
human cancer cell lines
 
Manitoba
 
Neisseria gonorrheae
 
P388 lymphocytic leukemia cells
 
riverbank soil
 
Streptomyces sp
 

George R Pettit