Significant expression of endoglin (CD105), TGFβ-1 and TGFβR-2 in the atherosclerotic aorta: An immunohistological study

Department of Pathology and Biodefense, Saga University Faculty of Medicine, Saga 849-8501, Japan.
Journal of atherosclerosis and thrombosis (Impact Factor: 2.73). 04/2006; 13(2):82-9.
Source: PubMed


To date, the glycoprotein endoglin and its receptor complex, formed between TGFbeta and TGFbeta R-2, have been studied in tumor angiogenesis. The purpose of this study is to investigate the expression profile of endoglin and its receptor complex in human atherosclerotic lesions, and compare it to that in non-atherosclerotic tissues. Twenty-six atherosclerotic lesions and twenty-six non-atherosclerotic aortic tissues were collected from thirty-six autopsy cases. Indirect immunohistochemical staining was performed to detect the presence of endoglin, TGFbeta-1, and TGFbeta R-2 proteins in aortic tissues. Endoglin expression was observed in smooth muscle cells (SMC), macrophages and endothelial cells of aortic atherosclerotic lesions. The levels of TGFbeta-1 and TGFbeta R-2 were increased in the intimal matrices, smooth muscle cells, and macrophages, as well as in endothelial cells. The expression levels of endoglin, TGFbeta-1, and TGFbeta R-2 were higher in atherosclerotic lesions than in non-atherosclerotic aortic tissues (p < 0.0001), and there was a correlation among the expression of endoglin, TGFbeta-1, and TGFbeta R-2 in atherosclerotic aortic lesions (p < 0.001). Endoglin or its receptor complex may participate in the atherogenesis.

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    • "talis arachnodactyliát contracturával. Transzaminázok hatására LTBP-keresztkötés alakul ki, ami szorosabb öszszeköttetést eredményez az extracelluláris mátrixhoz, mesenchyma-és endotheliumsejtekhez [33] [34] [35] [36]. "
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    Orvosi Hetilap 10/2014; 155(40):1575-1583. DOI:10.1556/OH.2014.30015
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    • "Another potential target for the PET imaging of atherosclerosis is CD105 (i.e. endoglin), where it was demonstrated that precursor atherosclerotic lesions exhibit intimal neovascularization that are associated with increased CD105 expression on endothelial cells 89-91. In addition, CD105 also plays a role in restenosis after stent placement 92, therefore can be used as a marker for the progression of coronary atherosclerosis. "
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    Theranostics 11/2013; 3(11):894-902. DOI:10.7150/thno.5506 · 8.02 Impact Factor
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    • "Immunohistochemical analysis revealed a weak expression of all studied markers in the vessel wall. On the other hand, they described simultaneous expression of TGF-1, endoglin and TβR-II in most atherosclerotic aortas in endothelium, macrophages and smooth muscle cells, suggesting the participation of these proteins in atherosclerosis (Piao and Tokunaga, 2006). "

    Atherogenesis, 01/2012; , ISBN: 978-953-307-992-9
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