Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathy.
ABSTRACT Polyoma virus nephropathy (PVN) is a significant cause of renal allograft dysfunction in transplant patients. A 58-year-old male received a cadaveric renal transplant and 12 weeks later presented with fever, diarrhea, and dysuria. He was diagnosed with a polyoma virus infection of the bladder by a transurethral bladder biopsy. One year post-transplant, he presented with renal allograft dysfunction and was diagnosed by biopsy with PVN of the non-native kidney. The diagnosis of a polyoma virus infection was confirmed by immunoreactivity to the polyoma T-antigen. We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post-transplant patients, as such infections might be an under-recognized comorbidity in individuals with PVN.
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ABSTRACT: Many infections can affect immunosuppressed renal allograft recipients either as systemic events or organ limited diseases. Some infections are restricted to the allograft. Here I will discuss the most important, clinically and diagnostically challenging productive viral infections found in kidney transplants. Table 1 lists helpful diagnostic clues when evaluating allograft biopsies.
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ABSTRACT: Dysfunction of the urinary bladder is often faced in kidney transplantation due to various structural, neurological, infectious, or other pathologies. As the goal is to obtain a well functioning urinary bladder or at least, a low-pressure reservoir without reflux, specific urologic examinations and therapies should be performed. This review based on a Medline and PubMed search as well as on international guidelines and personal experience, reflects the actual knowledge in the field of pretransplant urologic evaluation as well as pre- and posttransplant optimal therapeutic options. The evaluation of these factors and interventional strategies will help to improve long-term transplant outcomes.Transplantation Proceedings 01/2011; 43(1):387-90. · 0.95 Impact Factor