R-R interval variation and sympathetic skin response in fibromyalgia.

Department of Physical Medicine and Rehabilitation, Elazig, Turkey.
Archives of Medical Research (Impact Factor: 2.41). 08/2006; 37(5):630-4. DOI: 10.1016/j.arcmed.2005.11.008
Source: PubMed

ABSTRACT This study proposed to assess the autonomic nervous system (ANS) functions in fibromyalgia (FM) by using two electrophysiological tests, sympathetic skin response (SSR) and the heart rate variability named R-R interval variation (RRIV).
Sympathetic skin response and RRIV were studied in 29 female patients with FM and 22 healthy age-matched female controls. R-R interval variation at rest (R%), during deep breathing (D%), the difference between D% and R% (D-R) and the ratio of D-R% (D/R) were determined. Pain threshold was measured using a mechanical algometer.
R-R interval variation at rest (R%) and D/R did not show significant difference between patients and controls, whereas D% and D-R were significantly lower in patients compared to controls. SSR latencies of patients' hands and feet had no significant difference compared to controls' hand and feet SSR latencies. SSR latencies of patients' hands correlated significantly with control point score, total myalgic score, Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale. Sympathetic skin response latencies of patients' feet correlated only with HARS.
Analysis of heart rate variability may be useful and complementary to clinical examination in patients with symptoms of dysfunction in cardiovascular reflex pathways.

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    ABSTRACT: Fibromyalgia syndrome which is appeared in the form of common pain in women is a musculoskeletal disorder. Heart rate variability (HRV) is a signal as measured time between each successive QRS time obtained from ECG signal. HRV parameters are associated with autonomic nervous system in literature. FMS affects patient's psychology. Consequently some psychological tests are applied to patients for evaluation of psychological effects. Beck Anxiety Inventory (BAI) Test being applied as writing and speaking is a test consisting of 21 questions. In the study, HRV signals obtained from FMS patients and control group are decomposed into wavelet packets using Wavelet Packet Transform (WPT) and frequency bands which related to autonomic nervous system are included to study. Wavelet Packets within these frequency bands are applied to inputs of multilayer perceptron artificial neural networks (MLPNN). BAI psychological test scores are included as target values for MLPNN and each input is trained and tested as relating to target values. According to obtained accuracy values, the packets within Very Low Frequency (VLF) band has minimum accuracy values, however the packets within Low Frequency + High Frequency (LF+HF) has the best accuracy values. This study is targeted on presenting a solution for clinical studies which are evaluated using psychological test scores by physiological support.
    Biomedical Engineering Meeting (BIYOMUT), 2010 15th National; 01/2010
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    ABSTRACT: The aim of this study was to determine the common dermatologic diagnoses and skin-related symptoms in a cohort of patients with fibromyalgia seen in a tertiary referral center. A retrospective chart review was performed of all patients with a fibromyalgia diagnosis from January 1 to December 31, 2008, whose diagnosis was confirmed in the Fibromyalgia and Chronic Fatigue Clinic at Mayo Clinic in Rochester, Minnesota. Charts were reviewed for dermatologic conditions and cutaneous symptoms. Demographic and clinical data were collected to assess the frequency of skin-related issues in patients with fibromyalgia. Of 2,233 patients screened, 845 patients met the inclusion criteria of having a confirmed diagnosis of fibromyalgia. Among these fibromyalgia patients, various dermatologic conditions and cutaneous problems were identified, including hyperhidrosis in 270 (32.0 %), burning sensation of the skin or mucous membranes in 29 (3.4 %), and various unusual cutaneous sensations in 14 (1.7 %). Pruritus without identified cause was noted by 28 patients (3.3 %), with another 16 patients (1.9 %) reporting neurotic excoriations, prurigo nodules, or lichen simplex chronicus. Some form of dermatitis other than neurodermatitis was found in 77 patients (9.1 %). Patients with fibromyalgia may have skin-related symptoms associated with their fibromyalgia. No single dermatologic diagnosis appears to be overrepresented in this population, with the exception of a subjective increase in sweating.
    Clinical Rheumatology 01/2014; 33(7). · 1.77 Impact Factor
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    ABSTRACT: Aim of the work The aim of this study was to evaluate clinically and electrophysiologically the autonomic nervous system changes associated with rheumatoid arthritis (RA). Patients and methods The present study included 25 patients with RA [22 women (88%)] and 30 apparently healthy control subjects [27 women (90%)]. A thorough clinical examination was carried out. Disease activity and functional disability were assessed. Tests for assessment of autonomic functions include active and passive orthostatic stress tests, and sympathetic skin response (SSR). The presence of abnormality in 2 tests or more was a clue for the presence of autonomic neuropathy (AN). Sural sensory nerve conduction study and posterior tibial motor nerve conduction study were done. Results There was a statistically significant decrease in standing systolic and diastolic blood pressure (BP) components of the active orthostatic stress test and SSR amplitude as well as statistically significant prolongation of SSR latency of RA patients when compared to control. Three patients (12%) had clinical symptoms suggestive of AN; increased to 14 patients (56%) when orthostatic stress tests and SSR were utilized. There were no statistically significant differences between patients with different disease activity score 28 with 4 variables grades of RA activity and SSR latency and amplitude. There were no statistically significant differences between patients with different Stanford Health Assessment Questionnaire Disability Index grades of RA functional disability and SSR latency and amplitude. Conclusions Autonomic neuropathy is a common extra-articular manifestation of RA affecting sympathetic and parasympathetic fibers.
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