Article

Effect of Tamarindus indica fruits on blood pressure and lipid-profile in human model: an in vivo approach.

Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Pakistan journal of pharmaceutical sciences (Impact Factor: 0.95). 05/2006; 19(2):125-9.
Source: PubMed

ABSTRACT Fruits of Tamarindus indica were evaluated for their effects on lipid profile, systolic and diastolic blood pressure and body weight in human subjects. Dried and pulverized pulp of T. indica fruits, at a dose of 15 mg/kg body weight, was found to reduce total cholesterol level (p = 0.031) and LDL-cholesterol level (p = 0.004) to a significant extent. Though the fruits exerted no conspicuous effect on body weight and systolic blood pressure, it significantly reduced the diastolic pressure as confirmed by independent sample t-test at 5% significance level.

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    ABSTRACT: The present investigation was carried out to evaluate the combined effect of Tamarindus indica and Emblica officinalis on serum enzyme profile and lipid profile after fluoride intoxication in albino rats. Both these medicinal plants have been used as a valuable ingredient of various medicines in India. Three groups of ten adult male albino rats were administered 14.29 mg/L fluoride drinking water (collected from the fluoride zone in Agra region) for 30, 45 and 60 days and another three groups of ten rats were treated first with fluoride water in the same way as mentioned above and then treated with combined T. indica (10gm/Kg body weight) and E. officinalis (500 mg/Kg body weight) fruit extract (mixed in ratio of 1:2) orally for 15, 30 and 45 days, respectively. Results showed a very highly significant (p<0.001) increase in serum AST, highly significant (p<0.01) in ALT and non-significant (p>0.05) increase in LDH after fluoride water intoxication; while a very highly significant (p<0.001) decrease in serum AST, highly significant (p<0.01) decrease in ALT and non-significant (p>0.05) decrease in LDH after combined T. indica and E. officinalis treatment, respectively. There were observed highly significant (p<0.01) increase in serum total cholesterol, LDL, VLDL, very highly significant (p<0.001) increase in TG and a very highly significant (p<0.001) decrease in HDL after fluoride intoxication; while a very highly significant (p<0.001) decrease in serum total cholesterol, LDL, VLDL, TG and a very highly significant (p<0.001) increase in HDL after combined T. indica and E. officinalis treatment, respectively. T. indica reduces the serum fluoride concentration through chelation bio-mechanism and provides nutrients; while E. officinalis acts as a strong antioxidant. We concluded that T. indica and E. officinalis have compensated the fluoride toxicity that affects the body metabolism.
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    ABSTRACT: : To evaluate the protective effect of tamarind pulp against fluoride (F)-induced oxidative stress in the liver, adult female Wistar rats were treated daily for 45 days with sodium fluoride (300 ppm NaF = 136.7 ppm fluoride ion) in drinking water, alone or in combination with tamarind pulp (20 mg/kg bw by oral intubation). Malondialdehyde (MDA), antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and ascorbic acid level in the liver, and levels of calcium and F, plus activities of aspartate transaminase (AST) and alanine transaminase (ALT) in serum were determined 24 hr after the last treatment. In the NaF-treated animals, a significant increase in MDA content and a concomitant decrease in antioxidant enzyme activities of SOD, CAT, GSH-Px, and the ascorbic acid level in liver and increased activities of AST and ALT, and increased calcium and F concentrations in serum were observed. Administration of tamarind pulp together with NaF produced significant amelioration in all parameters studied, indicating that tamarind pulp is able to prevent free radical induced oxidative stress by F, attributable to its antioxidant property. It is concluded that tamarind pulp may be useful to prevent the oxidative damage caused by consumption of excessive amounts of F.
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    05/2014; 3(3). DOI:10.14419/ijbas.v3i3.2580

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