Article

Effect of Tamarindus indica fruits on blood pressure and lipid-profile in human model: an in vivo approach.

Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Pakistan journal of pharmaceutical sciences (Impact Factor: 0.95). 05/2006; 19(2):125-9.
Source: PubMed

ABSTRACT Fruits of Tamarindus indica were evaluated for their effects on lipid profile, systolic and diastolic blood pressure and body weight in human subjects. Dried and pulverized pulp of T. indica fruits, at a dose of 15 mg/kg body weight, was found to reduce total cholesterol level (p = 0.031) and LDL-cholesterol level (p = 0.004) to a significant extent. Though the fruits exerted no conspicuous effect on body weight and systolic blood pressure, it significantly reduced the diastolic pressure as confirmed by independent sample t-test at 5% significance level.

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Available from: Sharif Akhteruzzaman, Jun 30, 2015
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    ABSTRACT: The present investigation was carried out to evaluate the combined effect of Tamarindus indica and Emblica officinalis on serum enzyme profile and lipid profile after fluoride intoxication in albino rats. Both these medicinal plants have been used as a valuable ingredient of various medicines in India. Three groups of ten adult male albino rats were administered 14.29 mg/L fluoride drinking water (collected from the fluoride zone in Agra region) for 30, 45 and 60 days and another three groups of ten rats were treated first with fluoride water in the same way as mentioned above and then treated with combined T. indica (10gm/Kg body weight) and E. officinalis (500 mg/Kg body weight) fruit extract (mixed in ratio of 1:2) orally for 15, 30 and 45 days, respectively. Results showed a very highly significant (p<0.001) increase in serum AST, highly significant (p<0.01) in ALT and non-significant (p>0.05) increase in LDH after fluoride water intoxication; while a very highly significant (p<0.001) decrease in serum AST, highly significant (p<0.01) decrease in ALT and non-significant (p>0.05) decrease in LDH after combined T. indica and E. officinalis treatment, respectively. There were observed highly significant (p<0.01) increase in serum total cholesterol, LDL, VLDL, very highly significant (p<0.001) increase in TG and a very highly significant (p<0.001) decrease in HDL after fluoride intoxication; while a very highly significant (p<0.001) decrease in serum total cholesterol, LDL, VLDL, TG and a very highly significant (p<0.001) increase in HDL after combined T. indica and E. officinalis treatment, respectively. T. indica reduces the serum fluoride concentration through chelation bio-mechanism and provides nutrients; while E. officinalis acts as a strong antioxidant. We concluded that T. indica and E. officinalis have compensated the fluoride toxicity that affects the body metabolism.