Panjrath GS, Jain D. Monitoring chemotherapy-induced cardiotoxicity: Role of cardiac nuclear imaging
Department of Internal Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA.Journal of Nuclear Cardiology (Impact Factor: 2.94). 06/2006; 13(3):415-26. DOI: 10.1016/j.nuclcard.2006.03.002
Cardiotoxicity may result from a range of chemotherapeutic agents. The prevalence of cardiotoxicity from certain cytotoxic agents is reported to be significantly high. In addition to serious side effects and increased long-lasting morbidity and mortality, dose limitation and suboptimal usage is an important adverse effect. Nuclear cardiac imaging has played a quintessential and important role in identifying patients at risk and in the prevention and reduction of cardiac injury resulting from cytotoxic agents. Despite exploring a number of other diagnostic imaging or biochemical tools for identification of cardiac injury, nuclear cardiac imaging in the form of radionuclide angiocardiography continues to be the most suitable and cost-effective tool for reducing the prevalence of cases of cardiac dysfunction resulting from chemotherapy. This article reviews the prevalence, mechanisms, and prevention strategies for cardiotoxicity associated with some of the commonly known cytotoxic agents and the role of nuclear cardiac imaging in its monitoring and prevention, along with recent advances in this area.
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ABSTRACT: Nuclear imaging harnesses the unique properties of radiopharmaceuticals in allowing us to non-invasively image physiological phenomena, anatomical structures, and metabolic reactions, as well as various physiological spaces and compartments in patients (1). Nuclear imaging plays an important role in the noninvasive evaluation of patients with established or suspected coronary artery disease. A number of different radiopharmaceuticals and scintigraphic imaging techniques are available for obtaining important diagnostic and prognostic information about myocardial per-fusion, metabolism, cardiac function, and myocardial necrosis in patients with cardiovascular disorders. This chapter briefly describes various cardiac nuclear imaging techniques, their applications in clinical practice, and the recent developments in this field.Essential Cardiology, 12/2005: pages 221-243;
- Nuclear Medicine Communications 03/2007; 28(2):69-73. DOI:10.1097/MNM.0b013e328025ae04 · 1.67 Impact Factor
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