Correlation between serum prostate specific antigen and prostate volume in Taiwanese men with biopsy proven benign prostatic hyperplasia.
ABSTRACT We studied the correlation between serum prostate specific antigen and the volume of different zones of the prostate in Taiwanese men with biopsy proven benign prostatic hyperplasia.
A total of 233 patients with a mean age of 71.4 years (range 42 to 89), serum prostate specific antigen less than 10 ng/ml and pathologically confirmed benign prostatic hyperplasia were enrolled in this study. Total prostate and transitional zone volumes were measured with transrectal ultrasonography. Peripheral zone volume was determined by subtracting transitional zone volume from total prostate volume. Correlations between patient age, total serum prostate specific antigen and the volume of each prostate zone were analyzed with the Pearson correlation coefficient. A linear regression model was used to determine the relationship between prostate specific antigen and prostate volume. The prostate specific antigen-prostate volume relationship in our patients was compared with published data on white and Japanese men.
Age did not significantly correlate with serum prostate specific antigen and prostate volume. Serum prostate specific antigen significantly correlated with the volume of each prostate zone. After log transformation the Pearson correlation coefficient between total prostate specific antigen and the volume of the whole prostate gland, the transitional zone and the peripheral zone were 0.369, 0.377 and 0.272, respectively (p <0.001). Taiwanese men had lower prostate volume per unit prostate specific antigen comparing with white men, while the prostate specific antigen-total prostate volume relationship between Taiwanese and Japanese men was similar.
In Taiwanese men with biopsy proven benign prostatic hyperplasia the volume of each prostate zone has significantly correlates with serum prostate specific antigen. The prostate specific antigen-total prostate volume relationship in Taiwanese men is different from that in white men. However, the prostate specific antigen-total prostate volume relationship between Taiwanese and Japanese men is similar.
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ABSTRACT: Aim: To investigate the utility of prostate-specific antigen velocity (PSAV) and PSAV per initial volume (PSAVD) for early detection of prostate cancer (PCa) in Chinese men. Methods: Between January 2009 and June 2012, a total of 193 men (aged 49-84 years, median 67 years) with at least 2 transrectal ultrasonography (TRUS) procedures and concurrent serum PSA measurements underwent prostate biopsy because of suspicion of PCa. The total group were classified into PCa and non-PCa groups, and the variables of the two groups were compared. Univariate and multivariate analyses were used to investigate which variables were predictove. The diagnostic values of PSAV, PSAVD and prostate-specific antigen density (PSAD) were compared using receiver operating characteristic (ROC) analysis. Results: Prostate cancer was diagnosed in 44 (22.8%) of the 193 men. There were significant differences between the groups in last and initial prostate volumes determined by TRUS, initial age, last serum PSA levels, PSAV, PSAD and PSAVD. After adjusting for confounding factors, the odds ratios of PCa across the quartile of PSAVD were 1, 4.06, 10.6, and 18.9 (P for trend <0.001).The area under the ROC curves (AUCs) of PSAD (0.779) and PSAVD (0.776) were similar and both significantly greater than that of PSA (AUC 0.667). PSAVD was a significantly better indicator of PCa than PSAV (AUC 0.736). There was no statistical significant difference between the AUC of PSAV and that of last serum PSA level. The sensitivity and specificity of PSAVD at a cutoff of 0.023ng in participants with last serum PSA levels of 4.0ng/mL-10.0ng was 73.7% and 70.7%, respectively. Conclusions: The results of this study demonstrated PSAVD may be a useful tool in PCa detection, especially in those undergoing previous TRUS examination.Asian Pacific journal of cancer prevention: APJCP 11/2012; 13(11):5529-33. DOI:10.7314/APJCP.2012.13.11.5529
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ABSTRACT: ObjectivesTo assess the relationship between prostate volume (PV), prostate specific antigen (PSA) and age in a cohort of Saudi men from the Urology Department, King Abdul Aziz University Hospital, Jeddah, Saudi Arabia. MethodsMedical records of 447 Saudi men aged 20–89 years with benign prostatic conditions seen between January 2003 and June 2009, were reviewed, retrospectively. Cases with PSA >10 ng/ml, proven prostate cancer, previous prostate surgery or those who received 5-alpha reductase inhibitors (5-ARIs) were excluded. The study population was categorized into seven successive age groups (20–89 years). The variables of age, PV and PSA were examined. Using mean PV of the 20–29 years age group and mean PSA of the 40–49 years age group as reference points, percentage differences in mean PV and mean PSA in subsequent age groups were determined. A p-value <0.05 was considered significant. Findings in Saudi patients were compared to other ethnicities. Results447 men were enrolled with mean age 64.2 years, mean PV 35.2 cc (range 7–184 cc) and mean PSA 2.2 ng/ml (range 0.18–10 ng/ml). Overall, 62% (277/447) had PV <30 cc and 8.7% (39/447) had PV ≥50 cc. Among individual age groups, most men had PV <30 cc, except the 70–79 years age group where 55.2% (53/96) had PV >30 cc. Percentage differences of PV and PSA in 80–89 years age group (+150% and +70%, respectively) were lower than in the 60–69 and 70–79 years age groups (+187% and +160%; +207.2% and +220% for PV and PSA, respectively). All variables demonstrated significant weak correlations; except PV and PSA which showed a significant positive relationship (p <0.0001; r=0.441). ConclusionPV and PSA are significantly and strongly correlated. PV and PSA in Saudi men are closer to Asian than white ethnicities. Key WordsProstate–volume–prostate specific antigen–prostatic hyperplasia–Saudi ArabiaAfrican Journal of Urology 01/2010; 16(4):117-123. DOI:10.1007/s12301-010-0025-4
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ABSTRACT: To investigate the relationship between prostate-specific antigen (PSA) and prostate volume in a histologically defined subset of Korean men confirmed to have benign prostatic hyperplasia (BPH) only from multicore biopsy of prostate. A total of 707 Korean men with a PSA level of 10 ng/mL or lower who were shown to have stromoglandular hyperplasia only from transrectal ultrasound (TRUS)-guided multicore biopsy of prostate were included in the study. We analyzed PSA and total prostate volume (TV) measured through TRUS by stratified age cohorts. We used Pearson correlation coefficient (r) and linear regression model to describe the relationship between variables. Serum PSA level significantly correlated with TV in all stratified age cohorts, with r ranging from 0.29 to 0.47 (all P <0.001). Meanwhile, the degree of correlation appeared to increase with age. The slope of linear regression showing an association of PSA and TV was 3.68. The PSA increase per unit prostate volume decreased with the advancing cohort of age when we excluded subjects 70 years or older. Although PSA was significantly correlated with TV, the exact nature of the relationship between PSA and TV in Korean men with biopsy-proven BPH may be different from that in other races. Further basic research on the pathophysiology of BPH is needed to explain such a racial difference.Urology 03/2008; 71(3):395-8. DOI:10.1016/j.urology.2007.10.019