Correlation between serum prostate specific antigen and prostate volume in Taiwanese men with biopsy proven benign prostatic hyperplasia.
ABSTRACT We studied the correlation between serum prostate specific antigen and the volume of different zones of the prostate in Taiwanese men with biopsy proven benign prostatic hyperplasia.
A total of 233 patients with a mean age of 71.4 years (range 42 to 89), serum prostate specific antigen less than 10 ng/ml and pathologically confirmed benign prostatic hyperplasia were enrolled in this study. Total prostate and transitional zone volumes were measured with transrectal ultrasonography. Peripheral zone volume was determined by subtracting transitional zone volume from total prostate volume. Correlations between patient age, total serum prostate specific antigen and the volume of each prostate zone were analyzed with the Pearson correlation coefficient. A linear regression model was used to determine the relationship between prostate specific antigen and prostate volume. The prostate specific antigen-prostate volume relationship in our patients was compared with published data on white and Japanese men.
Age did not significantly correlate with serum prostate specific antigen and prostate volume. Serum prostate specific antigen significantly correlated with the volume of each prostate zone. After log transformation the Pearson correlation coefficient between total prostate specific antigen and the volume of the whole prostate gland, the transitional zone and the peripheral zone were 0.369, 0.377 and 0.272, respectively (p <0.001). Taiwanese men had lower prostate volume per unit prostate specific antigen comparing with white men, while the prostate specific antigen-total prostate volume relationship between Taiwanese and Japanese men was similar.
In Taiwanese men with biopsy proven benign prostatic hyperplasia the volume of each prostate zone has significantly correlates with serum prostate specific antigen. The prostate specific antigen-total prostate volume relationship in Taiwanese men is different from that in white men. However, the prostate specific antigen-total prostate volume relationship between Taiwanese and Japanese men is similar.
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ABSTRACT: Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in prostate growth and are overexpressed in benign prostatic hyperplasia (BPH). In this study, we investigated whether single nucleotide polymorphisms (SNPs) of the FGFR genes (FGFR1 and FGFR2) were associated with BPH and its clinical phenotypes in a population of Korean men. We genotyped four SNPs in the exons of FGFR1 and FGFR2 (rs13317 in FGFR1; rs755793, rs1047100, and rs3135831 in FGFR2) using direct sequencing in 218 BPH patients and 213 control subjects. No SNPs of FGFR1 or FGFR2 genes were associated with BPH. However, analysis according to clinical phenotypes showed that rs1047100 of FGFR2 was associated with prostate volume in BPH in the dominant model (GA/AA versus GG, P = 0.010). In addition, a significant association was observed between rs13317 of FGFR1 and international prostate symptom score (IPSS) in the additive (TC versus CC versus TT, P = 0.0022) and dominant models (TC/CC versus TT, P = 0.005). Allele frequency analysis also showed significant association between rs13317 and IPSS (P = 0.005). These results suggested that FGFR genes could be related to progression of BPH.Disease markers 01/2013; 35(6):869-875. · 2.17 Impact Factor
- Urological Science 06/2010; 21(2):93-95.
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ABSTRACT: To investigate the relationship between prostate specific antigen (PSA) level and prostate volume (PV) according to age in a community-based population of Korean men enrolled in a large-scale screening program. A total of 35,223 men who enrolled in the Korean Prostate Health Council Screening Program from January 2001 to December 2011 were included in this study. Patients with a serum PSA level of >10 ng/mL or younger than 40 years were excluded. We analyzed PSA level and PV as measured through transrectal ultrasonography according to stratified age cohorts. We used Pearson correlation and linear regression analysis according to age to describe the correlation between PSA level and PV. Mean PSA level and mean PV increased significantly with age (all P values <.001). Based on data from 5 age cohorts, mean PSA level increased about 0.3 ng/mL every 10 years and mean PV increased about 3 mL every 10 years. The slope of the linear regression between PSA level and PV was 4.582, and the slope of the linear regression increased with age. We derived equations relating PSA level and PV for the various age cohorts. Based on a large-scale health screening program, we derived equations relating PSA level to PV according to age group. These data provide a baseline for the normal population by avoiding the interventional bias of urinary symptoms, in contrast to previous data derived from patients who visited hospitals because of prostate-related health concerns.Urology 12/2013; 82(6):1394-9. · 2.13 Impact Factor