Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women.

Department of Toxicology, National Food Administration, P. O. Box 622, 75126 Uppsala, Sweden.
Osteoporosis International (Impact Factor: 4.17). 06/2006; 17(7):1055-64. DOI: 10.1007/s00198-006-0109-y
Source: PubMed

ABSTRACT Consumption of coffee and tea, and total intake of caffeine has been claimed to be associated with osteoporotic fracture risk. However, results of earlier studies lack consistency.
We examined this relation in a cohort of 31,527 Swedish women aged 40-76 years at baseline in 1988. The consumption of coffee, caffeinated tea and the intake of caffeine were estimated from a self-administered food frequency questionnaire (FFQ). Multivariate-adjusted hazards ratios (HRs) of fractures with 95% confidence intervals (95% CIs) were estimated by Cox proportional hazards models.
During a mean follow-up of 10.3 years, we observed 3,279 cases with osteoporotic fractures. The highest (>330 mg/day) compared with the lowest (<200 mg/day) quintile of caffeine intake was associated with a modestly increased risk of fracture: HR 1.20 (95% CI: 1.07-1.35). A high coffee consumption significantly increased the risk of fracture (p for trend 0.002), whereas tea drinking was not associated with risk. The increased risk of fracture with both a high caffeine intake and coffee consumption was confined to women with a low calcium intake (<700 mg/day): HR 1.33 (95% CI: 1.07-1.65) with > or =4 cups (600 ml)/day of coffee compared to <1 cup (150 ml)/day. The same comparison but risk estimated for women with a high propensity for fractures (> or =2 fracture types) revealed a HR of 1.88 (95% CI: 1.17-3.00).
In conclusion, our results indicate that a daily intake of 330 mg of caffeine, equivalent to 4 cups (600 ml) of coffee, or more may be associated with a modestly increased risk of osteoporotic fractures, especially in women with a low intake of calcium.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Trigonelline (1-methylpyridinium-3-carboxylate), an alkaloid present in coffee and fenugreek seed, has been reported to exhibit phytoestrogenic activity. The aim of the present study was to investigate the effects of trigonelline on bone mechanical properties of rats with normal estrogen level and estrogen deficiency (developing osteoporosis).
    Molecular Nutrition & Food Research 05/2014; 58(7). · 4.91 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Coffee is the second most universally consumed liquid substances, second to water (Linskog et al., 2002). There are many studies with positive findings that shows coffee is beneficial to human health. Coffee affects the body in many different ways and the most obvious affect is that being an energy boost, which became the main reason why people drink it. Coffee is rich in antioxidants, such as 'chlorogenic acid' and 'melanoidins'. Antioxidants help prevent oxidation, a process that causes damage to cells and contributes to aging. Regular coffee drinking also reduces the risk of Parkinson's disease. Saaksjarvi et al. (2008) and Hu et al. (2007) have demonstrated that people who drink coffee on a regular basis are significantly less likely to develop Parkinson's disease. Meanwhile, Shino et al. (2010) revealed that coffee consumption exerted a protective effect against type 2 diabetes. vanDam et al. (2006) also found that moderate consumption of both caffeinated and decaffeinated coffee may lower the risk of type 2 diabetes in younger and middle aged women. Coffee drinking may also protect against liver diseases, especially liver cirrhosis. A Japanese study (Inoue et al., 2005) found that those who drank coffee daily, or close to it, had about half the risk of hepatocellular carcinoma (HCC), a type of liver cancer. There is some evidence from Leitzmann et al. (2002) that coffee drinking may be protective against gallstone formation (known as 'cholelithiasis') in both men and women. In addition, coffee consumption lowers the risk of kidney stone formation where coffee increases the urine volume, preventing the crystallization of calcium oxalate, which is the most common component of kidney stones. Coffee consumption may also associate with decreased risk of kidney cancer (Lee et al., 2007a). Coffee can also improve mental performance. Caffeine in coffee is a well-known stimulant where it can promotes alertness, attention and wakefulness. Regular coffee drinking may help to protect against Alzheimer's disease. A study by Cao et al. (2011) revealed that a yet unidentified mystery ingredient in coffee interacts with the caffeine to help protection from Alzheimer's disease. A study by Arendash et al. (2006) in mice showed that caffeine equivalent to 5 cups of coffee per day reduced the build-up of destructive plaques in the brain. For people with asthma, caffeine can also open airways and improve asthma symptoms due the relationship between caffeine and theophylline, an old asthmatic medication. Furthermore, a large study by Wilson et al. (2011) of nearly 50,000 men found that men who drank 6 cups of coffee per day had 60% lower risk of lethal prostate cancer and those who drank 3 cups per day had 30% lower risk. Lee et al. (2007b) also suggested that coffee consumption may lower colon cancer risk among women and a study by Nettleton et al. (2010) revealed a beneficial effect of coffee on the pulmonary function of non-smokers. Women who drank more than 1 cup of coffee per day also had about 25% lower risk of stroke than women who drank less (Larrson et al., 2010). Meanwhile, a study by Garcia et al. (2009) found that women who drank 4 or more cups of coffee per day reduced their stroke risk by 20%. From a study by Jaquet et al. (2009) showed that coffee produced an increase in the metabolic activity and numbers of Bifidobacterium, which are beneficial bacteria in the gut.
    Buletin SSMP. 06/2013; 6:16.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A complex interplay between genetic and environmental factors is thought to be involved in the etiology of Parkinson's disease (PD). A recent genome-wide association and interaction study (GWAIS) identified GRIN2A, which encodes an NMDA-glutamate-receptor subunit involved in brain's excitatory neurotransmission, as a PD genetic modifier in inverse association with caffeine intake. Here in, we attempted to replicate the reported association of a single nucleotide polymorphism, GRIN2A_rs4998386, and its interaction with caffeine intake with PD in patient-control study in an ethnically homogenous population in southeastern Sweden, as consistent and independent genetic association studies are the gold standard for the validation of genome-wide association studies. All the subjects (193 sporadic PD patients and 377 controls) were genotyped, and the caffeine intake data was obtained by questionnaire. We observed an association between rs4998386 and PD with odds ratio (OR) of 0.61, 95% confidence intervals (CI) of 0.39-0.96, p = 0.03, under a model excluding rare TT allele. There was also a strong significance in joint effects of gene and caffeine on PD risk (TC heavy caffeine vs. CC light caffeine: OR = 0.38, 95%CI = [0.20-0.70], p = 0.002) and gene-caffeine interaction (OR = 0.998, 95%CI = [0.991-0.999], p<0.001). Overall, our results are in support of the findings of the GWAIS and provided additional evidence indicating PD protective effects of coffee drinking/caffeine intake as well as the interaction with glutamate receptor genotypes.
    PLoS ONE 06/2014; 9(6):e99294. · 3.53 Impact Factor

Full-text (2 Sources)

Available from
May 17, 2014