Article

Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes.

The Division of Diabetes and Metabolism, Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Diabetic Medicine (impact factor: 2.9). 07/2006; 23(6):617-22. DOI:10.1111/j.1464-5491.2006.01849.x pp.617-22
Source: PubMed

ABSTRACT Recent studies have provided increasing evidence that hepatocyte growth factor (HGF) has a pathophysiological role in the development of diabetic complications. We set out to determine the relationship between serum HGF and risk factors for macroangiopathy including carotid atherosclerosis. Carotid atherosclerosis is an established and important risk factor for both cerebral and coronary artery diseases.
We studied 89 patients (48 males, 41 females, mean age 62.5 +/- 10.3 years) with Type 2 diabetes (DM).
Serum levels of HGF correlated positively with both intimal-media thickness (IMT) (r = 0.24, P = 0.0248) and plaque score (r = 0.27, P = 0.0126). In multiple regression analysis, serum HGF was associated independently with IMT (standardized beta = 0.28, P = 0.0499). We also found that both IMT and plaque score were higher in patients with ischaemic heart disease (IHD) than in patients without IHD, and that plaque score in patients with lacunar infarcts was higher than in patients without lacunar infarcts.
Serum HGF concentration may be a new marker of atherosclerotic complications in patients with Type 2 DM.

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Keywords

41 females
 
89 patients
 
atherosclerotic complications
 
carotid atherosclerosis
 
coronary artery diseases
 
hepatocyte growth factor
 
HGF correlated
 
intimal-media thickness
 
ischaemic heart disease
 
lacunar infarcts
 
multiple regression analysis
 
plaque score
 
Recent studies
 
risk factor
 
risk factors
 
serum HGF
 
Serum HGF concentration
 
standardized beta
 
Type 2 diabetes
 
Type 2 DM
 

K Satani