Article

Hemopoietic precursors: mechanisms of regulation under conditions of chronic stress.

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Bulletin of Experimental Biology and Medicine (impact factor: 0.27). 12/2005; 140(5):616-20. pp.616-20
Source: PubMed

ABSTRACT We studied the content of hemopoietic precursor cells in the bone marrow, production of IL-1, IL-3, and colony-stimulating and erythropoietic activities by bone marrow cells under conditions of chronic stress. It was shown that in mice subjected to 15-h immobilization no hyperplasia of the bone marrow developed against the background of increased content of committed erythro- and granulomonocytopoietic precursors and enhanced production of short-distant humoral regulators of hemopoiesis, which reflects dysregulation of hemopoietic cells proliferation and differentiation processes in stressed animals.

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Keywords

chronic stress
 
differentiation processes
 
erythro-
 
erythropoietic activities
 
granulomonocytopoietic precursors
 
hemopoiesis
 
hemopoietic cells proliferation
 
hemopoietic precursor cells
 
IL-3
 
mice
 

E Yu Sherstoboev