Article

Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Japan.
Organic & Biomolecular Chemistry (impact factor: 3.7). 07/2006; 4(12):2354-7. DOI:10.1039/b603818b pp.2354-7
Source: PubMed

ABSTRACT A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis.

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Keywords

inhibitory activities
 
low molecular weight CXCR4 antagonists
 
strong CXCR4 antagonists