Article

Adjuvant taxanes in the treatment of breast cancer: No longer at the tip of the iceberg

Department of Medicine, Breast Cancer Medicine Service Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Clinical Breast Cancer (Impact Factor: 2.63). 05/2006; 7(1):51-8. DOI: 10.3816/CBC.2006.n.013
Source: PubMed

ABSTRACT Breast cancer is one of the leading causes of cancer-related mortality, and a cure is desperately needed. Adjuvant chemotherapy with anthracycline-based regimens has been proven to decrease the risk of relapse and cancer-related mortality in women with early-stage breast cancer. The taxanes (paclitaxel and docetaxel) have been incorporated into several adjuvant chemotherapy regimens in recent studies. Some of these trials are now mature and have demonstrated a definitive benefit with the use of taxanes. Thus, taxanes should be incorporated into the adjuvant treatment of breast cancer. To date, the available data do not allow one to select a single best taxane, schedule, or overall regimen.

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