Striatal Functional Alteration in Adolescents Characterized by Early Childhood Behavioral Inhibition

Department of Psychiatry, Virginia Commonwealth University, Ричмонд, Virginia, United States
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience (Impact Factor: 6.34). 07/2006; 26(24):6399-405. DOI: 10.1523/JNEUROSCI.0666-06.2006
Source: PubMed


The temperamental style of behavioral inhibition has been characterized by exaggerated behavioral and neural responses to cues signaling threat. Virtually no work, however, has addressed whether behavioral inhibition may also confer heightened brain activation in response to positively valenced incentives. We used event-related functional MRI (fMRI) and a monetary incentive delay task to examine whether the neural response to incentives is also greater in adolescents characterized as behaviorally inhibited early in life compared with those characterized as non-inhibited. Whereas task performance did not differ between groups, fMRI revealed greater striatal activation to incentives in behaviorally inhibited adolescents than in non-inhibited adolescents. This was regardless of whether the incentive was an anticipated gain or loss. Alteration in neural systems underlying behavior modulated by both negative and positive contingencies may represent a correlate of behavioral inhibition that also underlies vulnerability to various forms of developmental psychopathology.

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    • "In addition, associations between insula volume and similar temperamental traits such as shyness have been reported (Yang et al., 2013). Although not initially hypothesized, group differences in amygdala–striatal iFC are consistent with previous task-based studies showing altered striatal function in behaviorally inhibited adolescents (Bar-Haim et al., 2009; Guyer et al., 2006; Helfinstein et al., 2011) and adolescents with an anxiety disorder (Guyer et al., 2012). In the present work, adults characterized with BI in childhood exhibited negative iFC of the striatum with both the left BLA and CMA, while the non-BI group showed no significant iFC in these circuits, a finding consistent with previous work with anxious adolescents (Roy et al., 2013). "
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    • "low-incentive (p < .005) and a subsequent threshold regarding the extent of the cluster that was beyond the size that could be found randomly 5% of the time (k = 588).Consistent with previous studies, e.g., Guyer et al. (2006), we found greater striatal activation in high vs. low incentive value at both T1 in mid-adolescents and at T2 in late adolescents/early adults, averaging across gain and loss trials (see Table 3). In regard to main effects of age, results revealed significant age effects (collapsing across trial valence and incentive value) only in the left precentral gyrus (see Table 3). "
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