Article

Early neonatal hypotension in premature infants born to preeclamptic mothers.

Department of Pediatrics, Division of Neonatology, University of Florida Health Science Center, Jacksonville, FL 32209, USA.
Journal of Perinatology (impact factor: 1.8). 09/2006; 26(8):471-5. DOI:10.1038/sj.jp.7211558 pp.471-5
Source: PubMed

ABSTRACT Early neonatal hypotension (ENH) is common in premature infants and has been claimed to occur more frequently in infants born to mothers with severe preeclampsia. Previous studies that showed a relationship between maternal preeclampsia and neonatal hypotension did not control for potential confounding factors such as birth weight and maternal treatment with magnesium sulfate (MgSO4).
To determine whether maternal preeclampsia is an independent risk factor for ENH.
We conducted a retrospective review of all viable singleton infants with gestational age of 23 to 30 weeks who were admitted to the neonatal intensive care unit over a 2-year period. ENH was defined as the persistence of the mean arterial pressure lower than the gestational age in weeks requiring volume expansion and inotropic support in the first 24 h of life.
One hundred and eighty four infants were enrolled. Seventy-five (41%) infants met the diagnostic criteria for ENH. Maternal preeclampsia, the presence of labor, maternal treatment with MgSO4, Apgar scores, birth weight, gestational age and respiratory distress syndrome were significantly associated with ENH by univariate analysis. Only gestational age and maternal preeclampsia were significantly associated with ENH by multiple logistic regression.
Gestational age and maternal preeclampsia were independent risk factors for ENH in our population of premature infants.

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Keywords

birth weight
 
diagnostic criteria
 
factors
 
first 24 h
 
Gestational age
 
independent risk factor
 
magnesium sulfate
 
maternal preeclampsia
 
maternal treatment
 
mean arterial pressure lower
 
MgSO4
 
mothers
 
multiple logistic regression
 
neonatal hypotension
 
neonatal intensive care unit
 
persistence
 
respiratory distress syndrome
 
severe preeclampsia
 
viable singleton infants
 
volume expansion