Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER.

Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
The Journal of Cell Biology (Impact Factor: 9.69). 08/2006; 174(1):11-7. DOI: 10.1083/jcb.200604036
Source: PubMed

ABSTRACT Peroxisomes have long been viewed as semiautonomous, static, and homogenous organelles that exist outside the secretory and endocytic pathways of vesicular flow. However, growing evidence supports the view that peroxisomes actually constitute a dynamic endomembrane system that originates from the endoplasmic reticulum. This review highlights the various strategies used by evolutionarily diverse organisms for coordinating the flow of membrane-enclosed carriers through the peroxisomal endomembrane system and critically evaluates the dynamics and molecular mechanisms of this multistep process.

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