A Strong Dose-Response Relation Between Serum Concentrations of Persistent Organic Pollutants and Diabetes Results from the National Health and Examination Survey 1999–2002

University of Oslo, Kristiania (historical), Oslo, Norway
Diabetes Care (Impact Factor: 8.42). 08/2006; 29(7):1638-44. DOI: 10.2337/dc06-0543
Source: PubMed


Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes.
Cross-sectional associations of the serum concentrations of POPs with diabetes prevalence were investigated in 2,016 adult participants in the National Health and Nutrition Examination Survey 1999-2002. Six POPs (2,2',4,4',5,5'-hexachlorobiphenyl, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin, 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin, oxychlordane, p,p'-dichlorodiphenyltrichloroethane, and trans-nonachlor) were selected, because they were detectable in >or=80% of participants.
Compared with subjects with serum concentrations below the limit of detection, after adjustment for age, sex, race and ethnicity, poverty income ratio, BMI, and waist circumference, diabetes prevalence was strongly positively associated with lipid-adjusted serum concentrations of all six POPs. When the participants were classified according to the sum of category numbers of the six POPs, adjusted odds ratios were 1.0, 14.0, 14.7, 38.3, and 37.7 (P for trend < 0.001). The association was consistent in stratified analyses and stronger in younger participants, Mexican Americans, and obese individuals.
There were striking dose-response relations between serum concentrations of six selected POPs and the prevalence of diabetes. The strong graded association could offer a compelling challenge to future epidemiologic and toxicological research.

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    • "To investigate the potential influence of dietary composition on POP accumulation and the potential link between accumulation of POPs in adipose tissue and obesity development, a series of animal feeding trials were performed. In several human studies, age exhibits the strongest correlation with tissue accumulation of POPs [11] [12] [13]. Therefore, we measured accumulation of POPs in adipose tissue in mice fed fish-oilenriched diets with different macronutrient compositions for 6 and 18 months and determined the effect on metabolic parameters and lifespan. "
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    • "Acute effects include skin and eye irritation, non-cardiogenic pulmonary edema , cardiovascular toxicity, coma, convulsions and severe muscle fasciculation [8]. Chronic effects in rats include decreased body weights, organ weight changes (liver, kidney, brain, heart and lung), reduced brain size [9], cell damage (neoplastic and histopathological lesions), tumors [10] and endocrine toxicity [11]. The aim of the present study is to evaluate, subchronic effect of karate formulation of lambda cyhalothrin well known insecticide on liver and pancreas of albino rats. "
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