Imipenem in Patients with Immediate Hypersensitivity to Penicillins

Catholic University of the Sacred Heart , Milano, Lombardy, Italy
New England Journal of Medicine (Impact Factor: 55.87). 07/2006; 354(26):2835-7. DOI: 10.1056/NEJMc053529
Source: PubMed
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    • "On the other hand, patients who are truly allergic to aztreonam can safely receive a β-lactam, except ceftazidime. Both, meropenem and imipenem are well tolerated in penicillin skin-test-positive patients who have a negative skin test to imipenem.48 However, patients with a history of penicillin allergy with a positive skin test to penicillin who require imipenem should receive it by graded challenge. "
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    ABSTRACT: Anaphylaxis is an increasingly prevalent problem in westernized countries. Therefore, it is of utmost importance that the increasing numbers of patients at risk for anaphylaxis receive proper education on the etiology and risk factors as well as appropriate treatment of anaphylaxis with epinephrine. The physician's role is crucial in order to educate the patients and care takers on effective measures to prevent anaphylaxis and empower them to take charge of early recognition and proper management of an anaphylactic reaction to prevent poor outcomes. This review summarizes the clinical presentation, triggers, avoidance, and management of anaphylaxis.
    Journal of Asthma and Allergy 07/2014; 7(7):95-104. DOI:10.2147/JAA.S48611
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    • "The usefulness of skin testing for carbapenems has not been determined. Moreover, the cross-reactivity between penicillins and carbapenems is unclear, as studies have reported conflicting findings [21,31-35]. Recently, Romano et al. [35] published two prospective studies on the utility of skin testing to detect immediate-type allergic reactions to imipenem-cilastatin and meropenem [36]. "
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    ABSTRACT: Antibiotic skin testing is a useful procedure for identifying patients with IgE-mediated hypersensitivity to antibiotics. The procedures, however, have not been standardized, and the testing is performed with diverse protocols in Korean hospitals wards. Thus, we examined the current practice of antibiotic skin testing in Korea. We sent questionnaires to 12 allergists working in secondary or tertiary referral hospitals and collected them by e-mail or fax. The questionnaire included items such as the types and concentrations of the tested antibiotics, the methods of antibiotic skin testing, and the interpretation of the results. All hospitals responded to the questionnaire. The antibiotic skin testing protocols were variable, inconsistent, and differed with regard to the type and concentrations of antibiotics, the volume injected, and the interpretation of the results. Moreover, the protocols differed from the commonly recommended procedures in the medical literature. Standardized guidelines for antibiotic skin testing are needed for the safe and effective use of antibiotics in Korea.
    The Korean Journal of Internal Medicine 06/2010; 25(2):207-12. DOI:10.3904/kjim.2010.25.2.207 · 1.43 Impact Factor
  • Nippon rinsho. Japanese journal of clinical medicine 02/1993; 51 Suppl:630-42.
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