Clinical Experiences of Cardiac Myxoma

Department of Thoracic and Cardiovascular Surgery, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, Korea.
Yonsei Medical Journal (Impact Factor: 1.29). 07/2006; 47(3):367-71. DOI: 10.3349/ymj.2006.47.3.367
Source: PubMed


Although cardiac myxoma is rare, it is the most common primary cardiac tumor. Seventy-four cases of cardiac myxoma that were surgically treated in our center between August 1980 and February 2005 were retrospectively reviewed. The mean patient age was 50.4 +/- 15.0 (range 7-80) years, and 53 patients (71.6%) were female. The most common preoperative symptom, occurring in 44 patients, was dyspnea. The interval from onset of symptoms to surgery was 9 months. Seventy cases were located in the left atrium, 3 in the right atrium and 1 in the right ventricle. The myxoma in the right ventricle could not be resected completely, due to severe infiltration. Cardiopulmonary bypass and aortic cross clamp times were 100.4 +/- 37.1 and 64.8 +/- 29.8 minutes, respectively. There were no hospital deaths, and 7 patients suffered from postoperative complications including atrial fibrillation in 2 cases. During the follow up period (mean 105.7 +/- 73.6 months), there was no tumor recurrence and 6 late deaths that were not related to the underlying tumor. There was no evidence of tumor growth in the cases with incomplete resection during the 14-month follow-up. In conclusion, in this study there was no recurrence of tumors after complete resection and surgical resection is considered to be the curative method of treatment for cardiac myxoma.

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Available from: Byung-Chul Chang,
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    • "Depending on the type and location of the tumor, symptoms will vary. Intracardiac tumors which are myxomatous may be pedunculated and mobile, and may swing wildly around the affected atria, potentially bouncing off the interior walls and inciting atrial fibrillation by this contact (Vermeulen et al., 2009; Yu et al., 2006). The treatment for these tumors is predominantly surgical, and reasonable success has been obtained in this manner (Chuaratanaphong et al., 1995; Ipek et al., 2005).Cardiac rhabdomyomas are a hallmark of tuberous sclerosis, and their natural history is that they recede from the time of birth onward. "

    Atrial Fibrillation - Basic Research and Clinical Applications, 01/2012; , ISBN: 978-953-307-399-6
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    • "Myxoma is commonly classified into simple (or sporadic) cardiac myxoma and complicated cardiac myxoma. The latter includes myxoma complex, familial myxoma and myxoma from multicenters , and represents about 7% of all cardiac myxo- mas [1] . Sporadic cardiac myxoma is usually found in middle-aged women, most in the left atrium (LA) as a solitary tumor, at a recurrence rate of 1%-3%. "
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    ABSTRACT: We report a case of myxoma with multiple recurrences in both the atrium and ventricle in a 26-year-old woman five years after the surgical removal of left atrial myxoma. Her 52-year-old mother had a similar medical history. To our knowledge, this was the first familial case who suffered multifocal cardiac myxoma recurrences without any sign of the myxoma complex. Based on our understanding of the mechanism of recurrence, the approaches to prevent the recurrence, and markers to predict recurrence, we propose that multifocal recurrences, as reported herein, may result from a combination of familial predisposition and multifocal onset. The bi-atrial surgical approach and transesophageal echocardiography are preferred for patients with recurrent cardiac myxomas, especially for those with multiple recurrences and familial myxoma. Immunological and genetic screenings may help to identify family members at risk for developing this disease.
    09/2011; 25(5):368-72. DOI:10.1016/S1674-8301(11)60049-3
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    • "The diagnosis is based on histopathological and immunohistochemical findings. Although atrial myxomas are typically benign, local recurrence due to inadequate resection or malignant change has been reported [Hemachandran 2003; Yu 2006]. Sudden death may occur in patients with atrial myxoma. "
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    ABSTRACT: Cardiac myxomas are rare benign tumors of the heart. The growth rate of these tumors remains unknown. Right atrial myxoma can simulate nonspecific constitutional symptoms, such as remittent or lasting fever, weight loss, and chronic anemia, and may escape timely diagnosis until the development of severe complications such as pulmonary hypertension due to embolism from fragments originating from the tumor mass or blockage of the right atrioventricular ostium or Budd-Chiari syndrome with acute abdominal pain. We present a case of a giant right atrial myxoma mimicking hepatic cirrhosis in a 52-year-old man.
    Heart Surgery Forum 02/2007; 10(2):E107-9. DOI:10.1532/HSF98.20061173 · 0.39 Impact Factor
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