Primary adenoid cystic carcinoma of the breast: Case report and review of the literature

Department of Internal Medicine, Fairview Hospital, 18101 Lorain Avenue, Cleveland, OH, USA.
International Seminars in Surgical Oncology 02/2006; 3(1):17. DOI: 10.1186/1477-7800-3-17
Source: PubMed


Adenoid cystic carcinoma (ACC) of the breast is a rare neoplasm accounting for 0.1% of all breast carcinomas, and presenting most commonly as a painful breast mass. In contrast to the aggressive nature of ACC at other sites, ACC of the breast has a favorable prognosis, lymph node involvement or distant metastases seldom occur. Treatment is basically of simple mastectomy. Chemotherapy, radiation and hormonal treatment have been infrequently used and evaluated. We report a case of ACC of the breast managed with mastectomy and review the literature.

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    • "ACC of the breast is a very rare malignancy, accounting for less than 0.1% of all breast neoplasms [1]. Most information on ACC of the breast is derived from individual case reports and clinical case series. "
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    ABSTRACT: Adenoid cystic carcinoma (ACC) of the breast is a very rare and indolent tumor with a favorable prognosis, despite its triple-negative status. Due to its rarity, there has been no consensus regarding treatments, and treatment guidelines have not been established. Here, we report on six patients with ACC of the breast. All of the patients initially presented with localized disease and no axillary lymph node metastases. Although some of our patients developed local recurrence or distant metastases, all patients had a favorable clinical course, and to date, none of the patients has died from complications of her disease. Here, we described the clinicopathologic features of ACC of the breast and review the current literature.
    Cancer Research and Treatment 01/2014; 46(1):93-7. DOI:10.4143/crt.2014.46.1.93 · 3.32 Impact Factor
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    • "Based on a substantially larger number of cases, we found a similar mean age at diagnosis as previously reported among 14 histologically confirmed breast-ACC cases diagnosed during 1952 to 1982 in the Connecticut Tumor Registry (mean age 64 years) [28]. Some series have similarly reported mean/median ages of 60 to 66 years at diagnosis [12,22,23,36,42], whereas others have described ages that are nearly one decade younger [17,20,21,24,25,32,34,41]. Breast-ACC often presents with a palpable [15,17,23-25,32,41] and tender [14,15,23,24,37,48,49] mass, which is variably detected on mammography and ultrasound [25,35-37,48,50-52]. Similar to what has been suggested in the literature, we found that tumor size varies widely. "
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    ABSTRACT: Adenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive data exist. We sought to provide new population-based information on breast-ACC incidence, relative survival, and associated cancer risk in the United States. Using data from the Surveillance, Epidemiology and End Results Program, we calculated age-adjusted incidence rates (IRs), IR ratios (IRRs), and relative survival for breast-ACC, and standardized incidence ratios (SIRs) for other cancers. Overall 338 women (IR = 0.92/1 million person-years) were diagnosed with breast-ACC during 1977 to 2006. Blacks had 39% lower IRs than Whites (IRR = 0.61, 95% confidence interval = 0.37 to 0.96), and IRs remained constant over the 30-year period. Ninety-five percent of cases presented with localized stage (n = 320; IR = 0.87), and the highest IRs were observed for estrogen receptor (ER)-negative/progesterone receptor (PR)-negative tumors (IR = 0.56). Like other typically ER-negative tumors, age-specific IRs increased until midlife and then plateaued. Five-year, 10-year, and 15-year relative survival was 98.1%, 94.9%, and 91.4%, respectively. The risk of female breast cancer was not increased following (SIR = 0.89, 95% confidence interval = 0.43 to 1.64) or preceding (SIR = 0.71, 95% confidence interval = 0.28 to 1.46) breast-ACC. Similarly, no association was observed for breast-ACC and risk of all other cancers combined, solid tumors, or lymphohematopoietic malignancies. Breast-ACC among women is characterized by ER-negative/PR-negative expression, rare regional lymph node involvement, a favorable prognosis with excellent survival, and absence of associated cancers. These findings reinforce the importance of tailored treatments for breast-ACC and lend credence to the apparent heterogeneity of basal-like breast cancers.
    Breast cancer research: BCR 07/2010; 12(4):R54. DOI:10.1186/bcr2613 · 5.49 Impact Factor
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    ABSTRACT: Adenoid cystic carcinoma (ACC) of the breast is a rare tumour. Its recognition as a special type of breast carcinoma is very important because its prognosis is better than the not-otherwise-specified invasive ductal carcinoma and its treatment may not include axillary dissection. Tubular adenosis (TA) is a very rare condition of the breast that is histologically benign; however, it has been described in association with invasive ductal carcinoma. There are scant data regarding the molecular genomic alterations in ACC of the breast and no data has been presented on TA. Herein, we provide a morphological characterisation of TA arising synchronically with ACC in the breast. To characterise these lesions, we performed ultrastructural analysis, three-dimensional reconstruction and molecular analysis using immunohistochemistry and comparative genomic hybridisation. The copy number alterations found in ACC were restricted to small deletions on 16p and 17q only, whereas the TA harboured gains on 1q, 5p, 8q, 10q, 11p and 11q and losses on 1p, 10q, 11q, 12q, 14q, 15q and 16q. These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC.
    Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 01/2008; 454(1):107-114. DOI:10.1007/s00428-008-0700-z · 2.65 Impact Factor
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