Article

Squamous cell carcinoma with sarcomatoid features of the vulva: a case report and review of literature.

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710 Seoul, Republic of Korea.
Gynecologic Oncology (impact factor: 3.89). 11/2006; 103(1):363-7. DOI:10.1016/j.ygyno.2006.05.031 pp.363-7
Source: PubMed

ABSTRACT A squamous cell carcinoma with sarcomatoid features of the vulva is an extremely rare malignancy of the female genital tract. This type of tumor is known to grow rapidly and associated with poorer clinical outcomes than those of squamous cell carcinoma of the vulva.
A 43-year-old woman presented to our institute with a 4-month history of an aggravated vulvar mass. A radical local excision, bilateral inguinal lymph node dissection and laparoscopic assisted vaginal hysterectomy were performed. The FIGO stage of the vulvar cancer was stage II (T(2)N(0)M(0)) and the pathologic finding was consistent with a poorly differentiated squamous cell carcinoma with extensive sarcomatoid features. No further treatment was given and there was no clinical evidence of recurrence during the 2 years of follow-up.
A squamous cell carcinoma with sarcomatoid features of the vulva is a tumor with aggressive biological behavior. To date, there have been only 15 cases of this disease reported in the literature. So, a collection and close study of these cases would be extremely useful in singling out and identifying the best treatment possible for this type of tumor.

0 0
 · 
0 Bookmarks
 · 
36 Views
  • Source
    Article: Vulvar squamous cell carcinoma with sarcoma-like stroma: a case report and review of the literature.
    Marco Petrillo, Giacomo Corrado, Arnaldo Carbone, Gabriella Macchia, Gabriella Ferrandina
    [show abstract] [hide abstract]
    ABSTRACT: Vulvar squamous cell carcinoma with sarcoma-like stroma represents an extremely rare histological entity showing the co-existence of both epithelial and mesenchymal features: these tumors, firstly described in the skin by Martin and Stewart in 1935 have been further described in other anatomic sites including oral cavity, larynx, breast, lung and oesophagus. The complexity of the histology, as well as its aggressive clinical behaviour makes the diagnosis and the exploitment of effective therapeutic approaches very difficult, so that no definitive guidelines for treatments are currently available. Here, we describe a case of advanced stage vulvar squamous cell carcinoma with sarcoma-like stroma showing an unfavourable prognosis despite the use of an aggressive multimodal approach. A revision of the currently published cases have been also provided.
    Diagnostic Pathology 10/2011; 6:95. · 1.64 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

4-month history
 
aggravated vulvar mass
 
bilateral inguinal lymph node dissection
 
cases
 
clinical evidence
 
extensive sarcomatoid features
 
female genital tract
 
FIGO stage
 
follow-up
 
poorer clinical outcomes
 
poorly differentiated squamous cell carcinoma
 
rare malignancy
 
sarcomatoid features
 
squamous cell carcinoma
 
vaginal hysterectomy
 
vulva
 
vulvar cancer