A patient using ziprasidone with polydipsia, seizure, hyponatremia and rhabdomyolysis

Department of Psychiatry, Uludag University Faculty of Medicine, Bursa, Turkey.
Progress in Neuro-Psychopharmacology and Biological Psychiatry (Impact Factor: 3.69). 01/2007; 30(8):1535-8. DOI: 10.1016/j.pnpbp.2006.05.020
Source: PubMed


We aimed to report a case with rhabdomyolysis related to hyponatremia and/or its correction. A 32-year-old male schizophrenic patient on ziprasidone treatment was admitted to the hospital following a seizure. Patient had primary polydipsia and secondarily developed hyponatremia. After the correction of hyponatremia, due to the high liver enzyme levels, he was diagnosed as rhabdomyolysis. Although the role of antipsychotics in this situation is speculative, development of rhabdomyolysis related to hyponatremia and/or its correction should not be underestimated and should be assessed thoroughly.

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