Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond

Department of Psychology, University of Illinois, Urbana-Champaign, Urbana, Illinois, United States
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience (Impact Factor: 6.75). 08/2006; 26(27):7151-5. DOI: 10.1523/JNEUROSCI.1790-06.2006
Source: PubMed

ABSTRACT Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

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