Effects of chronic treadmill running on neurogenesis in the dentate gyrus of the hippocampus of adult rat. Brain Res
Department of Sport and Exercise Sciences, Graduate School of Sport Sciences, Osaka University of Health and Sport Sciences, Asashirodai1-1, Kumatori-cho, Sennan-gun, Osaka 590-0496, Japan.Brain Research (Impact Factor: 2.84). 09/2006; 1104(1):64-72. DOI: 10.1016/j.brainres.2006.05.066
Proliferating astrocytes and proliferating neuroblasts have been observed in the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus of adult rats under normal conditions. However, whether these proliferating cells are stimulated by running has not been determined. Using immunohistochemical techniques, we examined the effects of chronic treadmill running on proliferating astrocytes (PCNA+/GFAP+ cells), proliferating neuroblasts (PCNA+/DCX+ cells) and newly generated postmitotic neurons (DCX+/NeuN+ cells) in the DG of the hippocampus of adult rats and also characterized the morphological features of PCNA+/GFAP+ cells and PCNA+/DCX+ cells. PCNA+/GFAP+ cells with few processes and PCNA+/DCX+ cells without long processes were detected in the SGZ, and we determined that these are morphological features of the astrocytes and neuroblasts with proliferative ability. Chronic treadmill running (at a speed of 22 m/min, 30 min/days for 7 days) significantly increased the numbers of PCNA+/GFAP+ cells and DCX+/NeuN+ cells, and the number of PCNA+/DCX+ cells tended to increase by chronic treadmill running. These results indicate that chronic treadmill running stimulates the proliferation of astrocytes in the SGZ. Furthermore, the present study indicates that chronic treadmill running increases DCX+/NeuN+ cells that are detected in a transient stage during the neuronal maturation process. These events may be the cellular basis mediating both running-induced increases of new neurons in the DG of the hippocampus and running-induced improvement of learning and memory functions of adult rats.
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- "tive effect on the spatial memory performance ( Sampedro - Piquero et al . , 2013 , 2014b ) as well as other previous researches showing also the cognitive benefits after this type of exer cise ( Ang et al . , 2006 ; Alomari et al . , 2013 ) . Besides , the forced exercise has more similarity with human exercise training than voluntary protocols ( Uda et al . , 2006 ) because it lasts for a restricted period of time and some times its forced character reflects the attitude of many human subjects toward exercise . The idea of combining EE and forced exercise at the same time is new in animal models , but not in human research , where the combina tion of physical and mental activity has shown positiv"
ABSTRACT: Our study examined how different housing conditions modulated the acquisition of a spatial reference memory task and also, a reversal task in the 4-radial arm water maze (4-RAWM). The animals were randomly assigned to standard or enriched cages, and, as a type of complementary stimulation along with the environmental enrichment (EE), a group of rats also ran 15 min/day in a Rotarod. Elevated-zero maze results allowed us to discard that our exercise training increased anxiety-related behaviors. 4-RAWM results revealed that the non-enriched group had a worse performance during the acquisition and also, during the first trial of each session respect to the enriched groups. Regarding the reversal task, this group made more perseverative errors in the previous platform position. Interestingly, we hardly found differences between the two enriched groups (with and without exercise). We also analysed how the reversal learning, depending on the previous housing condition, modulated the expression of c-Fos positive nuclei in different subdivisions of the medial prefrontal cortex (Cingulate (Cg), Prelimbic (PL) and Infralimbic (IL) cortices) and in the Orbitofrontal (OF) cortex. The enriched groups had higher c-Fos expression in the Cg and OF cortices and lower in the IL cortex respect to the non-enriched animals. In the PL cortex, we did not find significant differences between the groups that performed the reversal task. Therefore, our short EE protocol improved the performance in a spatial memory and a reversal task, whereas the exercise training, combined with the EE, did not produce a greater benefit. This better performance seemed to be related with the specific pattern of c-Fos expression in brain regions involved in cognitive flexibility. Copyright © 2015. Published by Elsevier Ltd.Neuroscience 08/2015; 307. DOI:10.1016/j.neuroscience.2015.08.038 · 3.36 Impact Factor
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- "Although the results differ somewhat from our hypothesis and previous studies (Kramer et al., 1999; Colcombe and Kramer, 2003; Hillman et al., 2006), improved general cognitive function was also observed in several studies that measured both general and selective improvement (Colcombe and Kramer, 2003) or general improvement only (Smith et al., 2010; Dai et al., 2013). Animal studies have indicated that physical activity leads to improvement in cognition-related molecular constructs, such as neurogenesis (Uda et al., 2006) and synaptogenesis (Eadie et al., 2005; Kempermann, 2008). Physical activity has also been linked to increased neurotrophic factors, such as brain-derived neurotrophic factor (BDNF; Cotman and Engesser-Cesar, 2002), and relationships between exercise, BDNF, and cognition have recently been established in human studies (Kim et al., 2011; Coelho et al., 2013). "
ABSTRACT: This study was designed to determine the relationship between physical activity and the task-switching aspect of executive function by investigating the modulating roles of age, modality of physical activity, and type of cognitive function using behavioral and event-related potential (ERP) assessments. Sixty-four participants were assigned to one of four groups based on age and history of physical activity: older adults performing endurance exercise (OEE), older adults practicing Tai Chi Chuan (OTC), older adults with a sedentary lifestyle (OSL), and young adults (YA). Study participants completed a task-switching task under homogeneous and heterogeneous conditions while ERPs were recorded. The results revealed that YA had shortest reaction times compared with the three older adults groups, with OSL exhibiting the longest reaction time. YA also exhibited shorter P3 latency than OSL. No differences were observed in P3 amplitude between YA, OEE, and OTC; however, all three groups had significantly larger P3 amplitude compared with OSL in both task conditions. In conclusion, age and participation in physical activity influence the relationship between physical activity and task-switching, and a positive relationship was observed regardless of the modality of physical activity and type of cognitive function. Our ERP findings support the model of the scaffolding theory of aging and cognition (STAC) and suggest that regular participation in endurance exercise and Tai Chi Chuan may have equivalent beneficial effects on cognition at the behavioral and neuroelectric levels.Frontiers in Aging Neuroscience 10/2014; 6:295. DOI:10.3389/fnagi.2014.00295 · 4.00 Impact Factor
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- "In this context, Huang et al. (2013) suggested that exercise-induced cognitive improvement of middle-aged rats might be associated with an increase on the capillaries density in the rat cortex. The exercise-induced astrogliosis here observed in the sham group is supported by previous studies which demonstrated an increase in astrocytic activation and proliferation of GFAP positive cells, in the subgranular zone of the hippocampus, in healthy exercised rats (Uda et al., 2006; Li et al., 2005; Saur et al., 2014). Besides, our findings are in accordance with Valentim et al. (1999) that observed an early and late increase in both immunocontent and GFAP phosphorylation rate in the hippocampus from ischemic rats, Fig. 3 "
ABSTRACT: Persistent effects of pre- and postischemic exercise on glial cells activation after global cerebral ischemia remains poorly understood. Here, we investigated the effect of both pre and postischemic treadmill exercise protocols (20 min/day during 2 weeks) on glial cells immunostaining in the hippocampus of Wistar rats submitted to global ischemia. A synergistic effect between ischemia and postischemic exercise on the astrocytic area was demonstrated. Postischemic exercise partially reversed the ischemia-induced increase on the area occupied by microglia, without any effect of pre-ischemic protocol. In conclusion, postischemic exercise distinctly modulates astrocyte and microglia immunostaining in the hippocampal dentate gyrus following global cerebral ischemia in Wistar rats.Brain Research 10/2014; 1587(1). DOI:10.1016/j.brainres.2014.08.068 · 2.84 Impact Factor
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