Cytologic and Architectural Mimics of Papillary Thyroid Carcinoma Diagnostic Challenges in Fine-Needle Aspiration and Surgical Pathology Specimens

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
American Journal of Clinical Pathology (Impact Factor: 2.51). 07/2006; 125 Suppl(Suppl 1):S135-44. DOI: 10.1309/YY72M308WPEKL1YY
Source: PubMed


In this paper, we review those pathologic entities that may mimic papillary thyroid carcinoma. These include specimen preparation and handling issues such as decalcification, frozen section, and artifacts occurring following fine-needle aspiration (FNA). Also discussed are true disease entities, including chronic lymphocytic thyroidits, benign papillary hyperplastic lesions, hyalinizing trabecular neoplasm, and post-FNA changes. Both the cytologic and histopathologic preparations containing these changes are reviewed and illustrated; guidelines for distinctions among these entities are provided.

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Available from: Zubair W Baloch, Jun 17, 2015
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    • "However, the cells are round with prominent nucleoli and an even chromatin pattern. Despite these changes, these lesions can be diagnosed as benign on the basis of the structure of papillae and nuclear cytologic features [72] [78] [90] [91] (Fig 9). The FNA specimens of solitary papillary hyperplastic nodules demonstrate cellular smears, transgressing vessels, papillary clusters, nuclear atypia and pleomorphism, the presence of intranuclear grooves, multinucleated giant cells, and cells with vacuolated cytoplasm. "
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