Complete H-1 and C-13 assignments of fluorinated analogs of dehydroepiandrosterone

Science and Engineering Group, RTI International, Research Triangle Park NC 27709-2194, USA.
Magnetic Resonance in Chemistry (Impact Factor: 1.56). 12/2006; 44(11):1051-3. DOI: 10.1002/mrc.1874
Source: PubMed

ABSTRACT The complete assignments of all H-1 and C-13 chemical shifts were made for the fluorinated dehydroepiandrosterone (DHEA) analog fluasterone, 2, and two potential in vivo metabolites 3 and 4. The assignments were made using a combination of one- and two-dimensional NMR techniques (H-1, C-13, gDQCOSY, gHSQC, gHMBC). Once the proton chemical shifts were assigned, the stereochemistry of the two hydroxylated analogs was determined using 2D ROESY experiments. Copyright (c) 2006 John Wiley & Sons, Ltd.

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