Chemopreventive potential of Tribulus terrestris against 7,12- dimethylbenz (a) anthracene induced skin papillomagenesis in mice.

Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur-302004, India.
Asian Pacific journal of cancer prevention: APJCP (Impact Factor: 1.5). 7(2):289-94.
Source: PubMed

ABSTRACT In the present investigation, the chemopreventive potential of aqueous extracts of the root and fruit of Tribulus terrestris (an Ayurvedic medicinal plant) on 7, 12 - dimethylbenz (a) anthracene (DMBA) induced papillomagenesis in male Swiss albino mice was studied. A significant reduction in tumor incidence, tumor burden and cumulative number of papillomas was observed, along with a significant increase in average latent period in mice treated orally with Tribulus terrestris suspension continuously at pre, peri and post-initiation stages of papillomagenesis as compared to the control group treated with DMBA and croton oil alone. Treatment with Tribulus terrestris suspension by oral gavage for 7 days resulted in a significant increase in the reduced glutathione content in the liver (P< 0.001 for both root and fruit extracts). Conversely, lipid peroxidation levels were significantly decreased (P< 0.001).

1 Bookmark
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The present study was undertaken to evalu-ate the cardioprotective activity of Tribulus ter-restris (Tt), a medicinal herb following isopro-terenol (ISP)-induced myocardial injury. The contribution of heat shock protein (HSP) 70, key anti-stress protein, endogenous antioxi-dants and oxidant -antioxidant balance in attenuating myocardial injury was further studied. Hydroalcoholic extract of Tt {1, 2.5, 5 & 10 mg/kg} were orally fed once a daily to Wistar rats for 21 days. On the 20 th and 21 st day, both control (ISP control) and Tt fed rats were challenged with ISP (85 mg/ kg, s. c. two doses at 24h intervals) induced myocardial necrosis. Histopathological evaluation, cardiac marker enzyme: Creatinine phospho -kinase(CPK) and antioxidative parameters: Glutathione (GSH), Thiobarbituric acid reac-tive substances (TBARS), Catalase (CAT), Glutathione peroxidase (GSHPx) and Superoxide dismutase (SOD) levels were esti-mated. Tt (2.5 mg/kg) intake per se upregulat-ed HSP 70; increased basal SOD, CAT activity (P<0.05) and caused a marked fall in basal TBARS levels (P<0.05) in comparison to sham. Following ISP challenge, significant oxidative stress with evidence of myocardial necrosis was observed in the ISP control group. ISP-induced changes in myocardial SOD, GSHPx and GSH were prevented by both the 2.5 and 10 mg/kg doses of Tt, though cellular injury was minimal with 2.5 mg/kg dose. The results emphasize that pre-treatment with Tt offered significant protection against ISP-induced myocardial necrosis through a unique property of enhancement of endogenous antioxidants, stabilization of cytoskeleton structure which in turn is attributed to HSP 70 expression along with fortified antioxidant defense system.
    01/2011; 1(1). DOI:10.4081/ams.2011.e9
  • Source
    P K Srivastava, A K Pandey
    [Show abstract] [Hide abstract]
    ABSTRACT: Natural products are known to play important role in pharmaceutical biology and have been important source of medicine for thousands of years. Even today, the World Health Organization (WHO) estimates that up to 80 percent of people still rely mainly on traditional medicines. As plants are one of the most important sources of medicines, a large numbers of drugs are derived such as morphine from Papaver somniferum, Aswagandha from Withania somnifera, Ephedrine from Ephedra vulgaris, Atropine from Atropa belladonna, Reserpine from Roulphia serpentina etc. These herbal plants are used as immunostimulants as an alternative to the drugs, chemicals and antibiotics currently is being used to control diseases. In this context, the use of medicinal plants and their originated products as potential therapeutic measures for modulating the immune response, biological and pharmacological activities to prevent and control diseases. The possible use of naturally available herbal plant such as Aloe vera, Urtica dioica and Zingiber officinale etc have been discussed.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to determine the effects of Tribulus terrestris extract (TT) on growth performance, disease resistance and histopathological changes in intestine and liver tissues of Oreochromis mossambicus (Peters, 1852) first-feeding fry before and after exposure to Streptococcus iniae. Five isonitrogenous and isocaloric diets were formulated to contain 0 (control), 200, 400, 600, and 800 mg kg−1 TT. After feeding for 45 days, fish were infected with S. iniae and mortalities recorded. Final weight, weight gain and SGR of tilapia fry fed the 400 mg kg−1 TT diet were significantly greater than that of control diet. In the challenge experiment, the best survival rate was obtained with 400 mg kg−1 TT supplementation. Infection by S. iniae appeared to have a negative effect on histopathological findings and outcome than did TT-800 used alone. However, administration of TT (200 or 400 mg extract kg−1) resulted in overall improvement in the intestine and liver histopathology, emphasizing the protective potential of TT. The present study suggests the protective potential of TT in alleviating intestinal and hepatic damage that can occur after a S. iniae infection. It was concluded that 400 mg kg−1 TT can enhance growth and disease resistance during first–feeding of O. mossambicus fry. This suggests that TT may be an alternative to antibiotics in controlling streptococcal disease in tilapia culture.
    Journal of Applied Ichthyology 06/2014; 30(5). DOI:10.1111/jai.12458 · 0.90 Impact Factor


Available from