A study on the antioxidant activities of some new benzazole derivatives.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, TR-06100 Tandogan, Ankara, Turkey.
Acta Biologica Hungarica (Impact Factor: 0.5). 07/2006; 57(2):201-9. DOI: 10.1556/ABiol.57.2006.2.7
Source: PubMed

ABSTRACT The in vitro antioxidant properties of some new benzazole derivatives (1-10) such as benzoxazoles, benzimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 1, 2, 4 and 6, showed potent scavenging effect on superoxide radical at 10(-3) M. Compound 8, 5-nitro-2-(phenoxymethyl)benzimidazole, strongly inhibited lipid peroxidation at 10(-3) M concentration.