Jackson, E.L. et al. PDGFR-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51, 187-199

Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco, California 94143, USA.
Neuron (Impact Factor: 15.05). 08/2006; 51(2):187-99. DOI: 10.1016/j.neuron.2006.06.012
Source: PubMed


Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRalpha in the adult SVZ. Specifically labeled PDGFRalpha expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRalpha in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias with some features of gliomas. The work demonstrates that PDGFRalpha signaling occurs early in the adult stem cell lineage and may help regulate the balance between oligodendrocyte and neuron production. Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation.

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    • "However, further examination of NG2 cells and the SVZ revealed that NG2 cells comprise a minority of cells, located mostly at the periphery of the SVZ, and are distinct from the Dlx2-expressing type C cells or neuroblasts that express Doublecortin (Komitova et al., 2009; Platel et al., 2009; Richardson et al., 2011). These studies also showed that NG2 cells are distinct from GFAP+ neural stem cells (type B cells) (Rivers et al., 2008; Komitova et al., 2009; Chojnacki et al., 2011), in contrast to an earlier study that showed expression of Pdgfra on type B cells (Jackson et al., 2006). Neural stem cells do generate NG2 cells, but this fate of neural stem cells seems to be a minor fate compared with their neurogenic fate and is highly region-specific. "
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