Obstructive azoospermia associated with chronic sinopulmonary infection and situs inversus totalis.

Department of Urology, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.
Urology (Impact Factor: 2.13). 08/2006; 68(1):204.e5-7. DOI: 10.1016/j.urology.2006.01.072
Source: PubMed

ABSTRACT We describe 2 cases of obstructive azoospermia associated with situs inversus and sinopulmonary infection due to ciliary defects. Electron microscopy of testicular sperm flagella demonstrated normal morphology with nine peripheral doublets surrounding a central pair and complete sets of inner and outer dynein arms. Electron microscopy of the nasal mucosa revealed partial defects of the dynein arms of cilia, although the "9+2" morphology was preserved. Our cases were considered unique variants of Young's syndrome but also had characteristic features of Kartagener syndrome, and thus support the hypothesis that Young's syndrome has a genetic etiology similar to that of Kartagener syndrome.

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