Obstructive azoospermia associated with chronic sinopulmonary infection and situs inversus totalis

Department of Urology, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.
Urology (Impact Factor: 2.19). 08/2006; 68(1):204.e5-7. DOI: 10.1016/j.urology.2006.01.072
Source: PubMed


We describe 2 cases of obstructive azoospermia associated with situs inversus and sinopulmonary infection due to ciliary defects. Electron microscopy of testicular sperm flagella demonstrated normal morphology with nine peripheral doublets surrounding a central pair and complete sets of inner and outer dynein arms. Electron microscopy of the nasal mucosa revealed partial defects of the dynein arms of cilia, although the "9+2" morphology was preserved. Our cases were considered unique variants of Young's syndrome but also had characteristic features of Kartagener syndrome, and thus support the hypothesis that Young's syndrome has a genetic etiology similar to that of Kartagener syndrome.

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    • "Mercury exposure is one proposed etiology for Young's syndrome, and in an elegant argument supporting this theory, Hendry et al. demonstrated the decreasing incidence of Young's syndrome in men born after mercury-containing teething powder and worm medications were banned in the United Kingdom (18). There is building evidence that modern day Young's syndrome may be genetic variations of Kartagener's syndrome (19,20) or CFTR gene mutations (21,22). Genetic testing should be performed in patients presenting with signs and symptoms of Young's syndrome. "
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    ABSTRACT: Obstructive azoospermia is a common cause of male infertility and can result from infection, congenital anomalies, or iatrogenic injury. Microsurgical vasal reconstruction is a suitable treatment for many cases of obstructive azoospermia, although some couples will require sperm retrieval paired with in-vitro fertilization. The various causes of obstructive azoospermia and recommended treatments will be examined. Microsurgical vasovasostomy and vasoepididymostomy will be discussed in detail. The postoperative patency and pregnancy rates for surgical reconstruction of obstructive azoospermia and the impact of etiology, obstructive interval, sperm granuloma, age, and previous reconstruction on patency and pregnancy will be reviewed.
    Clinics 12/2012; 68(Suppl 1):61-73. DOI:10.6061/clinics/2013(Sup01)07 · 1.19 Impact Factor
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    • "Current scientific literature has scarcely analyzed the correlation between those systemic disorders and fertility in males. A few data highlight, for instance, that men with a rare condition called ciliary dyskinesia often present with chronic respiratory tract infections or infertility [44], with either asthenozoospermia [45] or azoospermia at semen analysis [46]. Connective tissue disorders have been also poorly investigated . "
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    ABSTRACT: An association between either subfertility or infertility and an elevated risk of certain male cancers has been previously reported. Nothing is known about abnormalities in infertility and general health conditions. To assess whether men with male factor infertility (MFI) are overall less healthy than fertile men, regardless of the reasons for infertility. From September 2006 to September 2007, 344 consecutive European Caucasian men with MFI were enrolled in this prospective case-controlled study. Patients were compared with a control group of 293 consecutive age-comparable fertile men. Infertile men were consecutively attending the outpatient male reproductive clinic at a tertiary academic center. Fertile controls were consecutively recruited by use of advertisements posted within our hospital. Comorbidities of patients and fertile men were objectively scored with the Charlson Comorbidity Index (CCI) according to the International Classification of Diseases modified ninth version (ICD-9-CM) codes. Multivariate linear regression models tested the association between predictors and CCI score, as a proxy of general health status. According to the CCI scores, infertile men had a significantly higher rate of comorbidities compared with the fertile controls (CCI: 0.33 [0.8] vs 0.14 [0.5]; p<0.001; 95% CI: 0.08-0.29). Linear regression analyses showed that although educational status did not have an impact on CCI (β: 0.035; p=0.365), while CCI linearly increased with age (β: 0.196; p<0.001) and body mass index (BMI; β: 0.161; p<0.001). After adjusting for age, BMI, and educational status, a significantly lower CCI was calculated for fertile men and compared with MFI patients (β: -0.199; p<0.001). These results show that MFI accounts for a higher CCI, which may be considered a reliable proxy of a lower general health status.
    European Urology 03/2009; 56(6):1025-31. DOI:10.1016/j.eururo.2009.03.001 · 13.94 Impact Factor
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    ABSTRACT: A thorough history and physical exam is a critical stepping stone towards the diagnosis and treatment of male infertility. This review focuses on obtaining a sexual, developmental, infection, medical, surgical and social history, providing an overview of medications that may impair a man’s fertility potential and performing a careful physical exam (see Table 1). The interpretation of hormonal, seminal and genetic testing is discussed in later chapters in association with specific disease entities.
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