Androgen and prolactin (Prl) levels in systemic sclerosis (SSc): relationship to disease severity.

U.O.C. Reumatologia--Cattedra di Reumatologia, Catholic University, Rome, Italy.
Annals of the New York Academy of Sciences (Impact Factor: 4.31). 07/2006; 1069:257-62. DOI: 10.1196/annals.1351.023
Source: PubMed

ABSTRACT Testosterone (T), sex hormone-binding globulin, (SHBG), dehydroepiandrosterone sulfate (DHEAS), and prolactin (Prl) serum levels were measured by electrochemiluminescense immunoassay (ECLIA) in 39 patients with systemic sclerosis (SSc) and compared with serum hormonal levels in control subjects matched for sex and reproductive status. A possible relationship with disease duration and disease severity was examined. Our data show an altered androgen and prolactin (Prl) status in SSc patients, in most cases related to disease duration and disease severity score. We can hypothesize that hormonal dysregulation is a consequence of the chronicity of the disease. The altered hormonal status could result in relative immunological hyperactivity contributing to enhance tissue damage and disease severity.

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