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Is aging part of Alzheimer’s disease, or is Alzheimer’s disease part of aging? Neurobiol Aging

Department of Neurology, University of Virginia Health System, McKim Hall, 1 Hospital Drive, P.O. Box 800394, Charlottesville, VA 22908, United States.
Neurobiology of aging (Impact Factor: 4.85). 11/2007; 28(10):1465-80. DOI: 10.1016/j.neurobiolaging.2006.06.021
Source: PubMed

ABSTRACT For 70 years after Alois Alzheimer described a disorder of tangle-and-plaque dementia, Alzheimer's disease was a condition of the relatively young. Definitions of Alzheimer's disease (AD) have, however, changed over the past 30 years and under the revised view AD has truly become an age-related disease. Most now diagnosed with AD are elderly and would not have been diagnosed with AD as originally conceived. Accordingly, younger patients that qualify for a diagnosis of AD under both original and current Alzheimer's disease constructs now represent an exceptionally small percentage of the diagnosed population. The question of whether pathogenesis of the "early" and "late" onset cases is similar enough to qualify as a single disease was previously raised although not conclusively settled. Interestingly, debate on this issue has not kept pace with advancing knowledge about the molecular, biochemical and clinical underpinnings of tangle-and-plaque dementias. Since the question of whether both forms of AD share a common pathogenesis could profoundly impact diagnostic and treatment development efforts, it seems worthwhile to revisit this debate.

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    • "Strikingly, the analysis revealed significant (Bonferroni corrected P = 0.0016) enrichment for genes (CDH13, GDF10, NTRK3, PENK, RBP1, RBP4, UCHL1, WIF1) whose expression values are known to be downregulated in early Alzheimer's disease [28]. Age is one of the biggest risk factors for developing Alzheimer's disease [29]. While DNA methylation is known to play a role in age-related neurodegenerative diseases such as Alzheimer's disease [30,31], our results indicate that a methylation footprint may also be found in blood tissue. "
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