Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear.
Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center, Tainan, Taiwan.Journal of Craniofacial Surgery (Impact Factor: 0.68). 08/2006; 17(4):797-800. DOI: 10.1097/00001665-200607000-00036
Giant cell tumor (GCT) is an uncommon primary bone tumor. The GCT mostly involves the extremity long bones. Rare is a GCT with tumoral growth in the cranium, especially other than the sphenoid bone. We herein report a 31-year-old male patient presenting with ipsilateral hearing loss and episodes of vertigo due to a large lobulated GCT of the right petrous temporal bone extending into the contiguous middle cranial fossa, infratemporal space, middle ear and external ear canal. He was treated with a macroscopically radical tumor excision followed by conventional megavoltage radiotherapy. The patient remains free of clinical and radiological evidences of tumoral recurrence six years after treatment. This experience supports the rationale for the combined treatment with radical excision plus irradiation toward this rare neoplasm when vigorous invasion of the skull base is encountered.
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- "Giant cell reparative granulomas (GCRGs) are benign osteolytic non-neoplastic granulomatous lesions of bone which occur most commonly in the maxilla and mandible in children and young adults. Lesions occurring outside the jaw have a second peak between the fifth and seventh decades of life. "
ABSTRACT: Giant cell reparative granulomas (GCRGs) are rare lesions in the cranial bones. We present a case of this rare lesion emanating from the clivus and replacing the sphenoid sinus, a highly unusual location for this entity. The case and clinical course of a 29-year-old female who presented with a large sphenoid mass are described here. The patient presented with symptoms of severe headache and diplopia; imaging demonstrated a large sphenoid mass which was completely resected via an endoscopic endonasal approach. It was based on the clivus and was shown to be a GCRG. GCRGs are benign granulomatous lesions which should be considered in the differential in the setting of a sphenoid mass.Surgical Neurology International 11/2012; 3(1):140. DOI:10.4103/2152-7806.103878 · 1.18 Impact Factor
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ABSTRACT: We report a very unusual presentation of giant cell tumor probably originated on the greater wing of the sphenoid and show a review about the knowledge and the treatment of the lesion in this rare localization. We treated a 48-year-old man with a giant cell tumor of the infratemporal fossa. He presented with a right-side hearing loss and facial pain. The tumor was resected by means of a subtemporal-preauricular approach, and after 12 months of follow-up, the patient is free of recurrence. Giant cell tumors of the skull base are an extremely rare neoplasm, and there is not much information on the literature about the treatment and the prognostic. Wide resection ought to be made, and at the follow-up, the clinician must try to diagnose not only local recurrence but also the possibility of distant metastases to the lung.Journal of Craniofacial Surgery 05/2008; 19(3):822-6. DOI:10.1097/SCS.0b013e31816aabee · 0.68 Impact Factor
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ABSTRACT: Giant cell tumour (GCT) of bone is an uncommon primary bone neoplasm typically occurring at the epiphyses of long bones in young adults. They are osteolytic neoplasms with approximate local recurrence rates of 25%, and 2% of patients develop pulmonary metastases. These tumours appear very rarely in the skull, with those few reported cases arising predominantly in the sphenoid and occasionally the temporal bones. They demonstrate benign histological features, but are locally aggressive and surgical excision is the treatment of choice. It is widely believed that giant cell tumours should be distinguished from other giant cell lesions, importantly central giant cell reparative granulomata (CGCG) which are thought to have a lower recurrence rate and for which no cases of malignant transformation or metastases have been reported. Investigators have noted that giant cell lesions in the skull bones may be unique and that GCT and CGCG may be part of a spectrum of a single disease process. We present a case of a giant cell tumour of the temporal bone which illustrates and re-emphasises this concept and review the literature on these lesions.Pathology & Oncology Research 12/2008; 15(2):291-5. DOI:10.1007/s12253-008-9124-y · 1.86 Impact Factor
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