Giant Cell Tumor of the Petrous Temporal Bone with Direct Invasion into the Middle Ear
Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center, Tainan, Taiwan.Journal of Craniofacial Surgery (Impact Factor: 0.68). 08/2006; 17(4):797-800. DOI: 10.1097/00001665-200607000-00036
Giant cell tumor (GCT) is an uncommon primary bone tumor. The GCT mostly involves the extremity long bones. Rare is a GCT with tumoral growth in the cranium, especially other than the sphenoid bone. We herein report a 31-year-old male patient presenting with ipsilateral hearing loss and episodes of vertigo due to a large lobulated GCT of the right petrous temporal bone extending into the contiguous middle cranial fossa, infratemporal space, middle ear and external ear canal. He was treated with a macroscopically radical tumor excision followed by conventional megavoltage radiotherapy. The patient remains free of clinical and radiological evidences of tumoral recurrence six years after treatment. This experience supports the rationale for the combined treatment with radical excision plus irradiation toward this rare neoplasm when vigorous invasion of the skull base is encountered.
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- "Giant cell reparative granulomas (GCRGs) are benign osteolytic non-neoplastic granulomatous lesions of bone which occur most commonly in the maxilla and mandible in children and young adults. Lesions occurring outside the jaw have a second peak between the fifth and seventh decades of life. "
ABSTRACT: Giant cell reparative granulomas (GCRGs) are rare lesions in the cranial bones. We present a case of this rare lesion emanating from the clivus and replacing the sphenoid sinus, a highly unusual location for this entity. The case and clinical course of a 29-year-old female who presented with a large sphenoid mass are described here. The patient presented with symptoms of severe headache and diplopia; imaging demonstrated a large sphenoid mass which was completely resected via an endoscopic endonasal approach. It was based on the clivus and was shown to be a GCRG. GCRGs are benign granulomatous lesions which should be considered in the differential in the setting of a sphenoid mass.Surgical Neurology International 11/2012; 3(1):140. DOI:10.4103/2152-7806.103878 · 1.18 Impact Factor
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ABSTRACT: We report a very unusual presentation of giant cell tumor probably originated on the greater wing of the sphenoid and show a review about the knowledge and the treatment of the lesion in this rare localization. We treated a 48-year-old man with a giant cell tumor of the infratemporal fossa. He presented with a right-side hearing loss and facial pain. The tumor was resected by means of a subtemporal-preauricular approach, and after 12 months of follow-up, the patient is free of recurrence. Giant cell tumors of the skull base are an extremely rare neoplasm, and there is not much information on the literature about the treatment and the prognostic. Wide resection ought to be made, and at the follow-up, the clinician must try to diagnose not only local recurrence but also the possibility of distant metastases to the lung.Journal of Craniofacial Surgery 05/2008; 19(3):822-6. DOI:10.1097/SCS.0b013e31816aabee · 0.68 Impact Factor
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ABSTRACT: Objectives: To demonstrate the importance of detailed clinical analysis in the differential diagnosis of malignant otitis externa and to provide an update on the current diagnostic tools available. Case reports: Two cases with malignancy presenting as otitis externa are reported. Both were treated initially with antibiotics; but failed to settle. CT scanning demonstrated lesions in the skull base in each case. Histology revealed two different and rare types of tumour. Conclusions: Patients with unresponsive otitis externa require imaging; and clinicians should be alert to other conditions that may mimic otitis externa.European Journal of Radiology Extra 07/2008; 67(1):9-12. DOI:10.1016/j.ejrex.2008.04.012
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