Article

Invasive micropapillary carcinoma of the urinary bladder: an immunohistochemical study of neoplastic and stromal cells.

Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Japan.
International Journal of Urology (impact factor: 1.75). 08/2006; 13(7):1015-8. DOI:10.1111/j.1442-2042.2006.01464.x pp.1015-8
Source: PubMed

ABSTRACT A 66-year-old man complained of hematuria. A cystoscopy revealed a non-papillary tumor and radical cystectomy was performed. Macroscopically, an ulcerative lesion was observed. Microscopically, the neoplasm showed a mixture of urothelial carcinoma, squamous cell carcinoma and micropapillary carcinoma. Immunohistochemically, micropapillary carcinoma cells were positive for cytokeratins 7 and 20, carcinoembryonic antigen and CA125. Additionally, myofibroblasts were distributed in a chicken-wire pattern in the stroma of micropapillary carcinoma. Subsequently, the patient died of carcinoma 1 year after the onset of symptoms. Our results support the previous hypothesis that bladder micropapillary carcinoma runs an aggressive clinical course and suggest that micropapillary carcinoma may show the glandular differentiation of urothelial carcinoma and show the stromal reaction by myofibroblasts resembling that of carcinoma in other anatomic sites.

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Keywords

66-year-old man
 
anatomic sites
 
bladder micropapillary carcinoma runs
 
carcinoembryonic antigen
 
carcinoma
 
carcinoma 1 year
 
chicken-wire pattern
 
glandular differentiation
 
Macroscopically
 
micropapillary carcinoma
 
micropapillary carcinoma cells
 
Microscopically
 
myofibroblasts
 
neoplasm
 
non-papillary tumor
 
results support
 
squamous cell carcinoma
 
ulcerative lesion
 
urothelial carcinoma
 

Naoto Kuroda