Article

Endothelin, the kidney, and hypertension.

Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, 39216-4505, USA.
Current Hypertension Reports (impact factor: 2.5). 09/2006; 8(4):298-303. DOI:10.1007/s11906-006-0068-x pp.298-303
Source: PubMed

ABSTRACT The kidneys play a central role in the long-term regulation of blood pressure and in the pathogenesis of hypertension. A common defect that has been found in all forms of hypertension examined to date is a hypertensive shift in the pressure-natriuresis relationship. A major objective of this brief review is to highlight some of the recent advances in our understanding of the mechanisms whereby the renal endothelin system, via endothelin type A- and endothelin type B-receptor activation, modulates renal pressure-natriuresis and blood pressure regulation under normal physiologic conditions and in certain forms of hypertension.

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Keywords

blood pressure
 
blood pressure regulation
 
brief review
 
central role
 
common
 
endothelin type B-receptor activation
 
hypertensive shift
 
modulates renal pressure-natriuresis
 
normal physiologic conditions
 
pathogenesis
 
pressure-natriuresis relationship
 
renal endothelin system
 

Joey P Granger