Modulation of Pituitary Adenylate Cyclase‐Activating Polypeptide (PACAP) Expression in Explant‐Cultured Guinea Pig Cardiac Neurons
University of Vermont College of Medicine, Department of Anatomy & Neurobiology, 149 Beaumont Avenue, HSRF 416A, Burlington, VT 05405, USA. Annals of the New York Academy of Sciences
(Impact Factor: 4.38).
08/2006; 1070(1):298-302. DOI: 10.1196/annals.1317.030
Pituitary adenylate cyclase-activating polypeptide (PACAP) expression was quantified in explant-cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP-immunoreactive neurons and pro-PACAP transcript levels increased significantly. Treatment with neurturin or glial-derived neurotrophic factor significantly suppressed the percentage of PACAP-IR neurons, but not pro-PACAP transcript levels.
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