Immunohistochemical Distribution of Amyloid Deposits in 25 Cows Diagnosed with Systemic AA Amyloidosis

National Institute of Animal Health, Tsukuba, Japan.
Journal of Veterinary Medical Science (Impact Factor: 0.78). 08/2006; 68(7):725-9. DOI: 10.1292/jvms.68.725
Source: PubMed


The distribution of amyloid deposits was histopathologically and immunohistochemically examined in 25 cows aged 5 to 10 years that had been diagnosed with systemic AA amyloidosis. This examination revealed that amyloid deposits were also present in the hypophysis, ovary, uterus, mammary gland and skeletal muscle, in addition to the liver, kidney, spleen, pancreas, thyroid gland, adrenal gland, gastrointestinal mucosa, heart, lung and lymph nodes. The examined cows tended to have chronic inflammations, including chronic mastitis (six cases) or chronic pneumonia (four cases), which is thought of as a causative agent of AA amyloidosis. In contrast, five cases did not exhibit any chronic inflammation.

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    • "Amyloid is a pathologic substance deposited between cells in various tissues and organs of the body in a wide variety of clinical settings including chronic inflammatory and neoplastic processes (Johnson & Jamison 1984; DiBartola et al. 1989; Fernández et al. 2003). Amyloidosis was determined in cattle with mastitis, pneumonia, TRP, traumatic pericarditis, salpingitis, and metritis (Johnson & Jamison 1984; Yamada et al. 2006). Although amyloidosis was reported in sheep with gangrenous pneumonia, purulent polyarthritis, pseudotuberculosis and abdominal abscess (Ménsua et al. 2003), to the best of our knowledge amyloidosis has not been reported together with TRP (Ménsua et al. 2003). "
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