Preparation of uniform biodegradable microparticles using laser ablation
Vaxdesign Inc., Orlando, FL 32826, USA.International Journal of Pharmaceutics (Impact Factor: 3.65). 12/2006; 325(1-2):194-6. DOI: 10.1016/j.ijpharm.2006.06.031
In an attempt to prepare uniformly sized biodegradable microparticles for controllable drug eluting and targeting characteristics, a novel technique by employing ultrashort pulse (USP) laser has been developed. This method involves pumping a drug-polymer solution through a small orifice creating a liquid stream. A USP laser constantly fires at the stream to cut it into discrete droplets and consequently solid particles can be obtained with monodisperse size distribution. Through mathematical modeling, volumetric flow rate, orifice size, laser spot size, and laser frequency were found as sole factors determining the size profile of the resulting microparticles. By choosing appropriate set of variables, monosized biodegradable microparticles with wide range of particle size may be prepared.
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ABSTRACT: Poly(lactic-co-glycolic acid) (PLGA) is the most often used synthetic polymer within the field of bone regeneration owing to its biocompatibility and biodegradability. As a consequence, a large number of medical devices comprising PLGA have been approved for clinical use in humans by the American Food and Drug Administration. As compared to the homopolymers of lactic acid poly(lactic acid) and poly(glycolic acid), the co-polymer PLGA is much more versatile with respect to the control over degradation rate. As a material for bone regeneration, the use of PLGA has been extensively studied for application include as either scaffolds, coatings, fibers or micro- and nanospheres to meet various clinical requirements.Tissue Engineering Part B Reviews 01/2013; 19(4). DOI:10.1089/ten.TEB.2012.0443 · 4.64 Impact Factor
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