Article

Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalis.

College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
Archives of Pharmacal Research (impact factor: 1.59). 08/2006; 29(7):541-7.
Source: PubMed

ABSTRACT Four alkaloids (1-4), three quinolone alkaloids (5-7), and three flavanoid glucosides (8-10) were isolated from the fruits of Evodia officinalis Dode, and their structures were determined from chemical and spectral data. Compounds, 3, 8, 9 and 10 were isolated from this plant for the first time. Of these compounds, 1-3 and 5-7 exhibited moderate cytotoxicities against cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7), and human hepatoblastoma (HepG-2). Compound 8 showed strong inhibitory effects on DNA topoisomerases I and II (70 and 96% inhibition at a concentration of 20 microM, respectively).

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    Article: Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa.
    Junlin Jiang, Changping Hu
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    ABSTRACT: Traditional Chinese herbs are regarded as a new and promising source of potential anti-cancer remedies and new chemotherapy adjuvants to enhance the efficacy of chemotherapy and/or to ameliorate its side effects. Extensive investigations have been undertaken both in the experimental and clinical studies over the years to augment the efficacy of chemotherapy. Evodia rutaecarpa is a very popular multi-purpose herb traditionally used in China for the treatment of headaches, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. The major constituents of Evodia rutaecarpa are evodiamine and rutaecarpine. Growing evidence demonstrates that evodiamine possesses anti-cancer activities both in vitro and in vivo by inhibiting proliferation, invasion and metastasis, inducing apoptosis of a variety of tumor cell lines. This review is aimed to summarize the recent researches on evodiamine focusing on anti-cancer activity and to highlight molecular mechanisms during the past ten years.
    Molecules 02/2009; 14(5):1852-9. · 2.39 Impact Factor
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Keywords

20 microM
 
5-7 exhibited moderate cytotoxicities
 
96% inhibition
 
Compound 8
 
compounds
 
cultured human colon carcinoma
 
flavanoid glucosides
 
human breast carcinoma
 
human hepatoblastoma
 
MCF-7
 
strong inhibitory effects