Article

Recurent miscarriage

Department of Obstetrics and Gynaecology, St Mary's Campus, Imperial College London, Mint Wing, South Wharf Road, London W2 1PG, UK.
The Lancet (Impact Factor: 45.22). 09/2006; 368(9535):601-11. DOI: 10.1016/S0140-6736(06)69204-0
Source: PubMed

ABSTRACT Many human conceptions are genetically abnormal and end in miscarriage, which is the commonest complication of pregnancy. Recurrent miscarriage, the loss of three or more consecutive pregnancies, affects 1% of couples trying to conceive. It is associated with psychological morbidity, and has often proven to be frustrating for both patient and clinician. A third of women attending specialist clinics are clinically depressed, and one in five have levels of anxiety that are similar to those in psychiatric outpatient populations. Many conventional beliefs about the cause and treatment of women with recurrent miscarriage have not withstood scrutiny, but progress has been made. Research has emphasised the importance of recurrent miscarriage in the range of reproductive failure linking subfertility and late pregnancy complications and has allowed us to reject practice based on anecdotal evidence in favour of evidence-based management.

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Available from: Lesley Regan, Jan 07, 2014
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    • "Infertility and recurrent pregnancy loss (RPL) are important reproductive phenotypes of multifactorial origin that affect up to 30% and 5– 15% of couples of reproductive age attempting a pregnancy, respectively (Rai and Regan, 2006; Boivin et al., 2007; Smith et al., 2011). Maternal comorbidities along with maternal and fetal genetic factors play a role in the etiology of these conditions, but despite extensive research, a cause cannot be identified in up to 13% (SART, 2010) of cases with unexplained infertility and 40 –50% (Allison and Schust, 2009) with RPL. "
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    • "Defined as the occurrence of two or more consecutive pregnancy losses, recurrent pregnancy loss (RPL) occurs before 24 weeks of pregnancy [1] [2] and affects approximately 5% of couples of who are in the reproductive period [3]. The most common risk factors for RPL include genetic, morphological, hormonal, metabolic, infectious, environmental, and immunological factors, as well as thrombophilia and advanced maternal age [4]. "
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    European Journal of Obstetrics & Gynecology and Reproductive Biology 08/2014; 182C:7-10. DOI:10.1016/j.ejogrb.2014.07.044 · 1.63 Impact Factor
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    • "It is a distressing condition for affected couples as each subsequent miscarriage leads to elevated risk of experiencing further pregnancy loss [Ogasawara et al., 2000] and increased probability of other pregnancy complications such as preterm delivery or small for gestational age newborns [Jivraj et al., 2001; van Oppenraaij et al., 2009]. Although a spectrum of factors is known to increase the risk to RM, including immune system dysfunction and thrombophilic disorders, the underlying etiology remains undetermined in about half of the cases [Rai and Regan, 2006; Allison and Schust, 2009]. A familial segregation of RM has been observed highlighting the contribution of the genetic predisposition to the disease [Christiansen et al., 1990; Kolte et al., 2011]. "
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