Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus?
We compare features of two similar nevi which may be confused with melanoma: deep penetrating nevus (DPN), and nevus with focal atypical epithelioid component (NFAEC).
Clinical/demographic and histologic information regarding 146 DPN and 81 NFAEC were compared. Patient outcomes were ascertained via a questionnaire solicited to the referring physicians.
Clinical features were similar for each type of nevus. Histologically, all lesions demonstrated identical aggregates of epithelioid melanocytes. DPN more often extended into the deep dermis or subcutaneous tissue, while NFAEC was typically confined to the superficial dermis. NFAEC more often demonstrated a junctional component (P < .001) and coexistent common nevus with congenital features (P = .035). DPN more often demonstrated adnexal spread (P < .001). A subgroup with overlapping features was identified. With an average of 6.4 years follow-up, there were just two recurrences, and no metastases.
This retrospective study utilized tissue specimens from a single reference laboratory; ergo, some inherent selection bias exists. Specimens were randomly selected for P53 immunostaining, leading also to potential sampling error.
DPN and NFAEC show considerable similarity, differing mainly in the depth of extent for the lesion. It is possible that NFAEC represents a more superficial variant of DPN. A subgroup with overlapping features, but intermediate depth, supports such a relationship.
Available from: Yi-Shing Lisa Cheng
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ABSTRACT: A 60-year-old man developed a mass on his forehead in his childhood. Histologic examination revealed a subcutaneous encapsulated cellular neoplasm consisting of mostly polygonal epithelioid cells, with abundant amphophilic cytoplasm and pleomorphic nuclei. There was one focal area of spindle cells. Numerous blood vessels of various sizes, small vacuoles and eosinophilic hyalinized material were also present. The morphologic features of the neoplasm did not fit with the typical features of any recognized pathologic entity. The subsequent immunohistochemical and electron microscopical evidence supported the diagnosis of epithelioid schwannoma, a rare variant of schwannoma that has not been reported in oral and maxillofacial pathology publications. The purpose of this report is to document a case and increase the awareness of this entity.
Journal of Oral Pathology and Medicine 12/2003; 32(10):612-7. DOI:10.1034/j.1600-0714.2003.00041.x · 1.93 Impact Factor
Journal of the American Academy of Dermatology 06/2007; 56(5):889-90. DOI:10.1016/j.jaad.2006.11.029 · 4.45 Impact Factor
Journal of the American Academy of Dermatology 06/2007; 56(5):890-1; author reply 891-2. DOI:10.1016/j.jaad.2006.10.989 · 4.45 Impact Factor
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