Sex differences in negative affective response during nicotine withdrawal.

Department of Psychology, The University of Wisconsin, Madison, Wisconsin 53706, USA.
Psychophysiology (Impact Factor: 3.18). 08/2006; 43(4):344-56. DOI: 10.1111/j.1469-8986.2006.00406.x
Source: PubMed

ABSTRACT This study examined physiological indicants of the neurobiological mediators of negative affect during acute nicotine withdrawal. Eighty subjects (41 male) were assigned to one of four groups (24-h deprived or nondeprived dependent smokers, occasional smokers, and nonsmokers) and participated in an instructed fear conditioning paradigm involving cued administration of electric shock. Negative affective response was measured with fear-potentiated startle during cues that signaled electric shock and during the postcue offset recovery period. Salivary cortisol and self-report measures were also collected. Fear-potentiated startle results indicated that affective recovery postcue offset was delayed in nicotine-deprived women. Nicotine-deprived women also displayed elevated cortisol levels throughout the fear conditioning procedure.

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