Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev 29: 83-91

Beijing Normal University, Peping, Beijing, China
Brain and Development (Impact Factor: 1.88). 04/2007; 29(2):83-91. DOI: 10.1016/j.braindev.2006.07.002
Source: PubMed


In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0+/-1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, [corrected] and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD.

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Available from: Yu-Feng Zang, Oct 06, 2015
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    • "Similar to the static CBF map, the ReHo map of each subject was divided by that subject's mean ReHo value, and one-sided one-sample t-test against 1 were performed on the normalized maps. (3) Amplitude of low-frequency fluctuations (ALFF) (Zang et al., 2007) was utilized to detect the strength of spontaneous fluctuations of the PASL signal in each voxel. Using REST, the time course of each voxel was transformed to the frequency domain, and ALFF was calculated as the amplitude integral over a frequency range of 0–0.125 Hz. "
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    • "Therefore, we took advantage of our unique behavioral techniques for assessing SS-induced tinnitus and hyperacusis in rats and combined this with focused electrophysiological measurements plus global fMRI assessment techniques to map out the regions of neural hyperactivity and enhanced FC that characterize the tinnitus–hyperacusis network. To identify regions of heightened or depressed spontaneous neural activity, we measured the amplitude of low-frequency fluctuations (ALFF) in resting-state fMRI (Zang et al., 2007; Zhang et al., 2010; Yao et al., 2012; Wen et al., 2013) and combined this with resting-state FC to identify regions of increased or decreased functional coupling between regions of the auditory pathway and other parts of the CNS. This is the first animal study to use ALFF and FC combined with detailed electrophysiological measures to provide a comprehensive neurological map of the tinnitus–hyperacusis network. "
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    eLife Sciences 05/2015; 4. DOI:10.7554/eLife.06576 · 9.32 Impact Factor
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    • "Both qualitative review (Rubia, 2011) and meta-analyses (Cortese et al., 2012; Hart, Radua, Nakao, Mataix-Cols, Rubia, 2013) on task-fMRI document hypoactivation of the components within the FPCN in ADHD across tasks. Rs-fMRI studies using various analytic methods also suggest involvement of the FPCN in ADHD (Cao et al., 2006; Posner et al., 2013; Qiu et al., 2011; Wang et al., 2009; Zang et al., 2007). However, to our knowledge, no studies have directly investigated the resting functional organization of the FPCN based on the aPFC, and how it underpins the cognitive/behavioral features of ADHD. "
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