Helicobacter and Digestive Malignancies

Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
Helicobacter (Impact Factor: 4.11). 11/2006; 11 Suppl 1(supplement 1):32-5. DOI: 10.1111/j.1478-405X.2006.00431.x
Source: PubMed


Important new data were published during the past year on the relationship of Helicobacter infection and gastric neoplasias. In the pathogenesis of gastric cancer, a thrilling new hypothesis was put forward based on animal experiments. Helicobacter infection induces gastric mucosal damage and bone marrow-derived cells (mobilized into peripheral blood and attracted to the inflamed mucosa) replace the areas of damaged gastric tissue and turn into neoplastic proliferation. Several studies focused on mechanisms related to the development of gastric malignancy in infected individuals with particular attention to inflammatory cytokine gene polymorphisms. Some new evidence is also reported to suggest that Helicobacter infection increases the risk of neoplasias outside the stomach in the liver and colon.

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Available from: Teresa Starzyńska, Feb 10, 2014
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    • "The cause of inflammation, and in a minority of patients dysplasia, is also unknown, even if a microbial cause is suspected [10]. Among the microbial species in the gastrointestinal tract, Helicobacter pylori infection is known to cause inflammation and dysplasia in the gastric mucosa and has emerged as a carcinogenic agent also in extragastric malignancies like colorectal and hepatic cancers [11]. The aim of the present study was to define the long-term quality of life in the patients with functional J-reservoirs and to evaluate what part of the patient's functional spectrum was especially affected. "
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    ABSTRACT: Objective. Study the functional results and mucosal changes in the ileal pouch after restorative proctocolectomy with J-reservoir for ulcerative colitis. Material and Methods. Followup study of 125 patients with J-reservoir with one disease-specific- and one general (SF-36) quality of life-questionnaire, rectoscopy with biopsies, and stool samples to evaluate inflammation, dysplasia, presence of Helicobacter pylori and calprotectin level. Results. Fourteen J-reservoirs were removed or deactivated, leaving 111 patients for followup. The followup time was 6.8 (1-15) years. 87.4% of the patients were satisfied. 93.1% had some kind of functional restriction: food- (75.5%), social- (28.9%), physical- (37%) or sexual restriction (15.3%). 18.6% had often or sometimes faecal incontinence. Low daytime faecal frequency was associated with good quality of life. 13 patients (12.6%) had a less favourable result. There was no pouch-dysplasia. Calprotectin levels were increased in patients with visible pouch inflammation or history of pouchitis. HP was diagnosed by RUT in 42.3%, but was not associated with inflammation or pouchitis. Conclusions. Most patients were satisfied with the J-reservoir in spite of a high frequency of various restrictions. 12.6% (13 patients) had a less favourable functional result, partly due to a high frequency of defecations, pain, pouchitis and inflammation.
    07/2011; 2011:430171. DOI:10.5402/2011/430171
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    • "In the present study, MPO and CAT activities were similar between the subjects included in the study. There are varying results on antioxidant enzyme activities in patients with gastric cancer.43-45 However, recent results are similar to present result. "
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    ABSTRACT: Helicobacter pylorus (HP) is a Gram-negative spiral-shaped microaerophilic bacterium, which colonizes in the gastric mucosa of humans. The gastric human pathogen HP causes chronic gastritis and ulcers, and has a strong relationship with gastric cancer. The aim of this study was to determine advanced oxidation protein products (AOPP) levels, activities of myeloperoxidase (MPO) and catalase (CAT) in two groups. For this aim, one group included 30 patients with gastric cancer (Group 1) and the other included 30 subjects with non-gastric cancer and Anti-HP immunoglobulin (Ig) G antibody positive (group 2). Anti-HP IgG antibody test values were found as positive in fifty percent of group 1 and all of the group 2 patients. Significantly increased AOOP levels were found in group 1 (p < 0.05) compared to group 2. There were no significant differences between the groups in regard to activities of MPO and CAT. In addition, AOPP level, MPO and CAT activities were similar among the Anti-HP IgG positive and negative subgroups of group 1 patients. The result of this study indicated that gastric cancer patients were characterized by increased protein oxidation, whereas there was no significant difference in oxidative stress parameters and antioxidant enzyme activity between the Anti-HP IgG positive and negative gastric cancer patients.
    Yonsei medical journal 10/2009; 50(5):677-82. DOI:10.3349/ymj.2009.50.5.677 · 1.29 Impact Factor
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    • "This work showed that BMDCs might fail to differentiate properly and progress to cancer only in the Helicobacter-infected environment. For a more detailed discussion of this topic, we refer to two recent reviews (Starzynska and Malfertheiner, 2006; Correa and Houghton, 2007). "
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    ABSTRACT: The association of Helicobacter pylori (H. pylori) with gastric cancer is thus far the best understood model to comprehend the causal relationship between a microbial pathogen and cancer in the human gastrointestinal tract. Besides H. pylori, a variety of other pathogens are now being recognized as potential carcinogens in different settings of human cancer. In this context, viral causes of human cancers are central to the issue since these account for 10-20% of cancers worldwide. In the case of H. pylori and gastric cancer, as well as the human papillomavirus and anal cancer, the causal relationship between the infectious agent and the related cancer in the gastrointestinal tract has been clearly confirmed by epidemiological and experimental studies. Similarly, Epstein-Barr virus and the oncogenic JC virus are being suggested as possible causative agents for cancers in the upper and lower gastrointestinal tract. This review discusses various viral and microbial pathogens and their oncogenic properties in the evolution of gastrointestinal carcinogenesis and summarizes the available experimental data make a convincing agreement favoring the associations between infectious agents and specific human cancers.
    Journal of Cellular Physiology 08/2008; 216(2):378-88. DOI:10.1002/jcp.21427 · 3.84 Impact Factor
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