Grid technology in tissue-based diagnosis: fundamentals and potential developments
ABSTRACT Tissue-based diagnosis still remains the most reliable and specific diagnostic medical procedure. It is involved in all technological developments in medicine and biology and incorporates tools of quite different applications. These range from molecular genetics to image acquisition and recognition algorithms (for image analysis), or from tissue culture to electronic communication services.
Grid technology seems to possess all features to efficiently target specific constellations of an individual patient in order to obtain a detailed and accurate diagnosis in providing all relevant information and references.
Grid technology can be briefly explained by so-called nodes that are linked together and share certain communication rules in using open standards. The number of nodes can vary as well as their functionality, depending on the needs of a specific user at a given point in time. In the beginning of grid technology, the nodes were used as supercomputers in combining and enhancing the computation power. At present, at least five different Grid functions can be distinguished, that comprise 1) computation services, 2) data services, 3) application services, 4) information services, and 5) knowledge services.
The general structures and functions of a Grid are described, and their potential implementation into virtual tissue-based diagnosis is analyzed. As a result Grid technology offers a new dimension to access distributed information and knowledge and to improving the quality in tissue-based diagnosis and therefore improving the medical quality.
SourceAvailable from: Marcial Garcia-Rojo[Show abstract] [Hide abstract]
ABSTRACT: Pathology informatics has evolved to varying levels around the world. The history of pathology informatics in different countries is a tale with many dimensions. At first glance, it is the familiar story of individuals solving problems that arise in their clinical practice to enhance efficiency, better manage (e.g., digitize) laboratory information, as well as exploit emerging information technologies. Under the surface, however, lie powerful resource, regulatory, and societal forces that helped shape our discipline into what it is today. In this monograph, for the first time in the history of our discipline, we collectively perform a global review of the field of pathology informatics. In doing so, we illustrate how general far-reaching trends such as the advent of computers, the Internet and digital imaging have affected pathology informatics in the world at large. Major drivers in the field included the need for pathologists to comply with national standards for health information technology and telepathology applications to meet the scarcity of pathology services and trained people in certain countries. Following trials by a multitude of investigators, not all of them successful, it is apparent that innovation alone did not assure the success of many informatics tools and solutions. Common, ongoing barriers to the widespread adoption of informatics devices include poor information technology infrastructure in undeveloped areas, the cost of technology, and regulatory issues. This review offers a deeper understanding of how pathology informatics historically developed and provides insights into what the promising future might hold.01/2013; 4(1):7. DOI:10.4103/2153-3539.112689
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ABSTRACT: Background: Tissue-based diagnosis or diagnostic surgical pathology is a highly accurate, sensitive and specific medical diagnostic technique that has expanded rapidly in using both molecular biology and computer technology. Objective: The objective is to analyze the present stage and potential influence of distributed data acquisition, analysis and presentation in tissue-based diagnosis by using recently developed standardized network systems such as grids. Methods: Interpretation of medical data is often based upon specialized examination, visual information acquisition and transfer as well as upon data collected from various sources. Efficient and accurate diagnostics require standardized data and transfer modes, which can be provided by a grid environment. The medical requirements, construction of an adequate grid environment, practical experiences in various medical disciplines and potential use in tissue-based diagnosis are described. Conclusions: Grid technology is probably a useful tool to meet the conditions of tissue-based diagnosis in the near future, and will probably play a significant role in its further development.Expert Opinion on Medical Diagnostics 03/2008; 2(3):323-37. DOI:10.1517/17530059.2.3.323
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ABSTRACT: The purpose of this paper is to study conditions under which a system of itinerate spin- fermions might exhibit a macroscopic linear response to external magnetic fields after long times. Exact expressions are obtained for the nonlinear response of the magnetization and the total energy. We find that for a constant field there is no response (our model contains no mechanism for the relaxation of spins). For an oscillatory field there is a response in which secular terms (in the time) appear which are associated both with nonlinear terms in the external field and with contributions from the background medium. The secular terms involving the magnetic field would not be seen if one used the usual approximations of microscopic linear response theory. They give rise to new conditions which must be satisfied if the system is to exhibit a macroscopic linear response in the long-time limit.Physica A: Statistical Mechanics and its Applications 02/1975; 79(3):312-337. DOI:10.1016/0378-4371(75)90031-X · 1.72 Impact Factor