Article

Repulsion or adhesion: receptors make the call.

Department of Zoology, Madison, WI 53706, USA.
Current Opinion in Cell Biology (Impact Factor: 8.74). 11/2006; 18(5):533-40. DOI: 10.1016/j.ceb.2006.08.010
Source: PubMed

ABSTRACT Repulsive signaling plays a prominent role in regulating cell-cell interactions and is fundamental to multiple developmental processes. A proper balance between repulsion from and adhesion to other cells or the extracellular matrix is also important. Semaphorin-Plexin and ephrin-Eph ligand-receptor pairs compose two major repulsive signaling systems. Recent advances have elucidated mechanisms by which Semaphorin-Plexin and ephrin-Eph signaling control repulsion versus adhesion. Semaphorins act through a complex signaling pathway to inhibit integrin-mediated adhesion, allowing cell repulsion. Ephrin-Eph interactions can directly mediate cell adhesion and several mechanisms control whether ephrin-Eph binding and signaling induces repulsion or adhesion.

0 Bookmarks
 · 
108 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities", which have long been considered to rely on differences in cell-cell adhesion. However, vertebrate embryonic tissues also express a variety of cell surface cues, in particular ephrins and Eph receptors, and there is now firm evidence that these molecules are systematically used to induce local repulsion at contacts between different cell types, efficiently preventing mixing of adjacent cell populations.
    Cell adhesion & migration 10/2014; 8(4). DOI:10.4161/19336918.2014.970028 · 3.40 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Embryonic boundaries are sharp delimitations that prevent intermingling between different cell populations. They are essential for the development of well-organized structures and ultimately a functional organism. It has been long believed that this process was driven by global differences in cell adhesion strength, or expression of different types of adhesion molecules. The actual picture turns out to be quite different: Boundaries should be viewed as abrupt discontinuities, where cortical contractility is acutely upregulated in response to specific cell surface contact receptors which act as repulsive cues. Cell adhesion is also modulated along the interface, in different ways depending on the type of boundary, but in all cases the process is subordinated to the function of the cortical actomyosin cytoskeleton. © 2015 Elsevier Inc. All rights reserved.
    Current Topics in Developmental Biology 01/2015; 112:19-64. DOI:10.1016/bs.ctdb.2014.11.026 · 4.21 Impact Factor
  • Source
    Symmetry 09/2014; 6(3):704-721. DOI:10.3390/sym6030704 · 0.92 Impact Factor

Preview

Download
2 Downloads
Available from