Blockade of postsynaptic activity in sleep inhibits developmental plasticity in visual cortex.
ABSTRACT Ocular dominance plasticity is enhanced by sleep and reduced by sleep deprivation or when all neural activity in the sleeping visual cortex is reversibly inhibited. These latter findings demonstrate that the mechanisms responsible for the effects of sleep on cortical plasticity are activity dependent. To better isolate this activity dependent mechanism, we investigated the role of postsynaptic activity by inactivating the sleeping visual cortex after a period of monocular deprivation with the gamma-amino-n-butyric acid agonist muscimol. Microelectrode recordings showed that ocular dominance plasticity was significantly reduced in cortices reversibly silenced during sleep compared with cortices infused with vehicle only. These findings demonstrate that postsynaptic activity during sleep is required for the consolidation of experience-dependent cortical plasticity.
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ABSTRACT: The aim of this report was to investigate the prospective links between infant sleep regulation and subsequent executive functioning (EF). The authors assessed sleep regulation through a parent sleep diary when children were 12 and 18 months old (N = 60). Child EF was assessed at 18 and 26 months of age. Higher proportions of total sleep occurring at night time, at both 12 and 18 months, were related to better performance on executive tasks, especially those involving a strong impulse control component. Most relations held above family socioeconomic status, prior mental development and concurrent verbal ability. These findings add to previous results with school-age children in suggesting that sleep favors the development of higher order cognitive functions requiring prefrontal cortex involvement.Child Development 11/2010; 81(6):1739-52. DOI:10.1111/j.1467-8624.2010.01507.x · 4.92 Impact Factor
- Principles of Medical Biology 01/1997; 8:529-546. DOI:10.1016/S1569-2582(97)80052-9
Conference Paper: An Internet routing emulation system: research and development[Show abstract] [Hide abstract]
ABSTRACT: With the incessant growth of Internet and renewal of routing protocols, it becomes a demanding task to measure the running characteristics of routing protocol implementations (RPI) in a real large-scale network. In the paper, we analyze the hierarchical Internet topology, and propose a method to transform the GT-ITM model to BGP-OSPF oriented Internet topology. We design and implement Internet Routing Emulation System (IRES) as a test bed to inspect the above characteristics by combining Internet topology generation and RPI. Using IRES, we measure and analyze the OSPF RPI on a CISCO2600 router, and give the upper bound of the network scale it supports. The main contribution in this paper include: 1) we develop IRES by combining the Internet topology generation and RPI, 2) we propose a novel approach to inspect the running characteristics of RPI in a realistic large-scale network, and demonstrate this approach by experiments with IRES.Communication Technology Proceedings, 2003. ICCT 2003. International Conference on; 05/2003