Blockade of postsynaptic activity in sleep inhibits developmental plasticity in visual cortex.
ABSTRACT Ocular dominance plasticity is enhanced by sleep and reduced by sleep deprivation or when all neural activity in the sleeping visual cortex is reversibly inhibited. These latter findings demonstrate that the mechanisms responsible for the effects of sleep on cortical plasticity are activity dependent. To better isolate this activity dependent mechanism, we investigated the role of postsynaptic activity by inactivating the sleeping visual cortex after a period of monocular deprivation with the gamma-amino-n-butyric acid agonist muscimol. Microelectrode recordings showed that ocular dominance plasticity was significantly reduced in cortices reversibly silenced during sleep compared with cortices infused with vehicle only. These findings demonstrate that postsynaptic activity during sleep is required for the consolidation of experience-dependent cortical plasticity.
SourceAvailable from: Reto Huber[Show abstract] [Hide abstract]
ABSTRACT: Sleep, specifically sleep slow-wave activity (SWA), contributes to global synaptic homeostasis in neocortical networks by downscaling synaptic connections that were potentiated during prior wakefulness. In parallel, SWA supports the consolidation of hippocampus-dependent episodic memory, a process linked to local increases in synaptic connectivity. During development, both SWA and episodic memory show parallel time courses: distinct SWA and capabilities to form episodic memory become established during infancy and then profoundly increase across childhood until puberty. We propose that the parallel increases across childhood reflect an imbalance in the underlying regulation of synaptic connectivity during sleep; although memory consolidation favoring synaptic potentiation is enhanced, global synaptic downscaling during sleep SWA does not attain complete recovery of homeostatic baseline levels.Trends in Cognitive Sciences 01/2014; DOI:10.1016/j.tics.2013.12.005 · 21.15 Impact Factor
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