A case of voltage-gated potassium channel antibody-related limbic encephalitis.

Addenbrooke's Hospital, Cambridge, UK.
Nature Clinical Practice Neurology (Impact Factor: 7.64). 07/2006; 2(6):339-43; quiz following 343. DOI: 10.1038/ncpneuro0194
Source: PubMed

ABSTRACT A 56-year-old man presented to hospital with a 6-month history of recurrent episodes of altered behavior and 'odd' episodes. He had become apathetic and uninterested in his family. He had no relevant past medical or family history. General and physical neurological examinations were unremarkable, as was bedside cognitive testing.
Brain MRI scan, 24-h electroencephalogram, serum and cerebrospinal fluid testing for voltage-gated potassium channel antibodies, blood screening for tumors, CT scans of the chest, abdomen and pelvis, whole-body PET scan, neuropsychological examination, brain 18F-fluorodeoxyglucose-PET scan.
Voltage-gated potassium channel antibody-related limbic encephalitis.
Antiepileptic drugs, immunomodulatory therapy, oral steroids, plasma exchange.

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